{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:43:53Z","timestamp":1793123033481,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>We report the formation of colchicine\u2010Cu<jats:sub>3<\/jats:sub>(PO<jats:sub>4<\/jats:sub>)<jats:sub>2<\/jats:sub> hybrid nanoflowers (Colc\u2010NFs) with intrinsic catalytic and antimicrobial activities with and without hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>). While the colchicine molecule, known as a secondary metabolite with anti\u2010inflammatory properties, was used as an organic part of Colc\u2010NFs, the Cu<jats:sup>2+<\/jats:sup> ion acted as an inorganic part of Colc\u2010NFs. The acetamide group in the colchicine structure may react with Cu<jats:sup>2+<\/jats:sup> ions in phosphate\u2010buffered saline to form Colc\u2010NFs. The Colc\u2010NFs exhibited both an intrinsic peroxidase\u2010mimic activity against guaiacol and antimicrobial activities against <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Staphylococcus aureus<\/jats:italic>, and <jats:italic>Candida albicans<\/jats:italic> in the presence of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. Both activities of the Colc\u2010NFs rely on a Fenton\u2010like reaction mechanism by producing reactive hydroxyl radicals. In addition to that high surface\u2010to\u2010volume ratio and porous structure of Colc\u2010NFs may contribute to their peroxidase\u2010mimic activities depending on the Fenton\u2010like reaction.<\/jats:p>","DOI":"10.1002\/cbdv.202500911","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T21:29:01Z","timestamp":1748381341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Formation of Colchicine\u2010incorporated Hybrid Nanoflower With an Intrinsic Peroxidase\u2010Mimic and Enhanced Antimicrobial Activities"],"prefix":"10.1002","author":[{"given":"Erdal","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Aquatic Animal and Diseases, Faculty of Veterinary Medicine Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih Dogan","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Aquatic Animal and Diseases, Faculty of Veterinary Medicine Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izzet Burcin","family":"Saticioglu","sequence":"additional","affiliation":[{"name":"Department of Aquatic Animal Diseases, Faculty of Veterinary Medicine Bursa Uludag University  Bursa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Ozen","sequence":"additional","affiliation":[{"name":"Department of Community Health Nursing, Faculty of Health Sciences Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek Demirezen","family":"Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Nisari","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Faculty of Dentistry University of Nuh Naci Yazgan  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-3934","authenticated-orcid":false,"given":"Ismail","family":"Ocsoy","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Erciyes University  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.80"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5dt01250c"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2015.04.010"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8ra03250e"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eti.2021.101992"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matlet.2021.130501"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.3c00260"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.201300020"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4tb01697a"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja3120136"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pat.4956"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22412"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201059699\u20105"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201073778\u20107"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2021.11.009"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.16882\/derim.2019.549151"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202300404"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/su15054638"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10266\u2010023\u201000857\u20102"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.05.025"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13204\u2010020\u201001577\u20107"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.07.133"},{"key":"e_1_2_10_24_1","unstructured":"Clinical and Laboratory Standards Institute.Performance Standards for Antimicrobial Susceptibility Testing: Twenty\u2010second Informational Supplement. 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