{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:07:32Z","timestamp":1753862852584,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Natural products remain a critical reservoir of lead compounds in the search for effective antimetastatic therapies for breast cancer. In the present study, we evaluated the inhibitory effects of three benzophenanthridine alkaloids against human breast cancer cells. One new benzophenanthridine alkaloid, (6<jats:italic>S<\/jats:italic>)\u20106\u2010\u03b2\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranosylsanguinarine (SGG, <jats:bold>1<\/jats:bold>), was isolated and identified from <jats:italic>Eomecon chionantha<\/jats:italic>, and decreased the cell viability of MDA\u2010MB\u2010231 cells with an IC<jats:sub>50<\/jats:sub> value of 32.688\u00a0\u00b5M, while showing limited toxicity in normal liver cells. SGG significantly inhibits the migration ability in MDA\u2010MB\u2010231 cells using wound healing assay. Furthermore, molecular docking studies revealed significant interactions between SGG and FN1, COL3A1, DCN, MUC1 with a binding energy of \u22128.98, \u22127.79, \u22127.49, and \u22127.77\u00a0kcal\/mol, respectively. According to ADMET and drug\u2010likeness assessment, SGG was identified as a promising candidate lead compound. Collectively, these findings identify SGG as a potential small\u2010molecule inhibitor of breast cancer metastasis.<\/jats:p>","DOI":"10.1002\/cbdv.202500936","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T16:15:14Z","timestamp":1750090514000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of a New Benzophenanthridine Alkaloid Suppressed the Growth and Migration of MDA\u2010MB\u2010231 Cells"],"prefix":"10.1002","author":[{"given":"Yuxiang","family":"Wan","sequence":"first","affiliation":[{"name":"College of Medicine &amp; Technology Hunan Polytechnic of Environment and Biology  Hengyang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Qi","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences Hunan University of Medicine  Huaihua People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueshuang","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences Hunan University of Medicine  Huaihua People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xie","sequence":"additional","affiliation":[{"name":"Xiangya Hospital, Central South University  Changsha People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-7558","authenticated-orcid":false,"given":"Peng","family":"Yang","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, School of Pharmaceutical Sciences Hunan University of Medicine  Huaihua People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.03.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.11.037"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.07.062"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2017.08.006"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b17-00451"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-020-03845-0"},{"issue":"7","key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"765","DOI":"10.2174\/1871520622666220831124321","article-title":"Molecular Mechanisms of Sanguinarine in Cancer Prevention and Treatment","volume":"23","author":"Ullah A.","year":"2023","journal-title":"Anti\u2010Cancer Agents in Medicinal Chemistry"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115565"},{"issue":"1","key":"e_1_2_9_11_1","doi-asserted-by":"crossref","first-page":"6642","DOI":"10.1038\/s41598-025-91251-1","article-title":"Ethoxychelerythrine as a Potential Therapeutic Strategy Targets PI3K\/AKT\/mTOR Induced Mitochondrial Apoptosis in the Treatment of Colorectal Cancer","volume":"15","author":"Meng Y.","year":"2025","journal-title":"Scientific Reports"},{"issue":"6","key":"e_1_2_9_12_1","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s10600-022-03876-7","article-title":"A New Alkaloid From Eomecon Chionantha","volume":"58","author":"Yang P.","year":"2022","journal-title":"Chemistry of Natural Compounds"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2022.2096606"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.202200871","article-title":"Cytotoxic Effects of the Benzophenanthridine Alkaloids Isolated From Eomecon chionantha on MCF\u20107 Cells and Its Potential Mechanism","volume":"20","author":"Yang P.","year":"2023","journal-title":"Chemistry & Biodiversity"},{"issue":"5","key":"e_1_2_9_15_1","first-page":"311","article-title":"Breast Cancer Metastasis","volume":"9","author":"Scully O. 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