{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:35:11Z","timestamp":1773873311659,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100014786","name":"Northern Border University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014786","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Schimpera arabica (Safra), growing wild in Egyptian deserts and the northern region of Saudi Arabia, has not been extensively studied. The ethyl acetate fraction of S. arabica methanol extract revealed significant antioxidant capacity and cytotoxicity. The reversed\u2010phase high\u2010performance liquid chromatography of the ethyl acetate fraction contains a variety of phenolic compounds, including quercetin\n                    <jats:bold>(6)<\/jats:bold>\n                    , luteolin\u20108\u2010C\u2010beta\u2010D\u2010glucopyranoside\n                    <jats:bold>(10),<\/jats:bold>\n                    trans\u2010cinnamic acid\n                    <jats:bold>(11)<\/jats:bold>\n                    , quercetin\u20103\u2010galactoside\n                    <jats:bold>(13)<\/jats:bold>\n                    , and naringenin\u20105,7\u2010di\u2010O\u2010glucoside\n                    <jats:bold>(15)<\/jats:bold>\n                    . The further cytotoxicity of ethyl acetate demonstrated a strong antiproliferative effect on the Huh\u20107 and HepG2 cell lines, with IC\n                    <jats:sub>50<\/jats:sub>\n                    s of 52.58 and 73.10 \u00b5g\/mL, respectively. The ethyl acetate fraction has a significant level of total phenolics (51.53\u00a0mg GAE\/g extract) and total flavonoids (59.25\u00a0mg RE\/g extract), according to a quantitative analysis of total phenolics. S. arabica may prove to be a viable source for the creation of natural antioxidants. High total phenolic and antioxidant activity suggests it may be a promising avenue for developing natural antioxidants. Molecular docking was carried out in the active site of NQO1. Naringenin 5,7\u2010di\u2010O\u2010glucoside\n                    <jats:bold>(15)<\/jats:bold>\n                    showed the highest binding energy due to its intricate HB with the target protein.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500946","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:39:02Z","timestamp":1751384342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Reversed\u2010Phase High\u2010Performance Liquid Chromatography\u2010based Phytochemical Screening, Molecular Modeling, Antioxidant and Cytotoxic Evaluation of the\n                    <i>Schimpera arabica<\/i>\n                    Hochst. &amp; Steud, From Northern Region Habitat"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2284-3466","authenticated-orcid":false,"given":"Eman R.","family":"Elsharkawy","sequence":"first","affiliation":[{"name":"Centre for Health Research Northern Border University Arar Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4017-7698","authenticated-orcid":false,"given":"Abdullah S. M.","family":"Aljohani","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences College of Veterinary Medicine, Qassim Univeristy Buraydah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0151-8309","authenticated-orcid":false,"given":"Fahad A.","family":"Alhumaydhi","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratories College of Applied Medical Sciences Qassim University Buraydah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9488-4019","authenticated-orcid":false,"given":"Mohammed I.","family":"Rushdi","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy South Valley University Qena Egypt"},{"name":"Medicinal Chemistry Department Faculty of Pharmacy South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelfattah","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy South Valley University Qena Egypt"},{"name":"Medicinal Chemistry Department Faculty of Pharmacy South Valley University Qena Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.11646\/phytotaxa.261.3.1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/d17020136"},{"issue":"4","key":"e_1_2_9_4_1","first-page":"1010","article-title":"Taxonomic Revision on Genus Brassica L. (Cruciferae A. Juss.) in Egypt","volume":"11","author":"Azer S. 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