{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:04:08Z","timestamp":1773493448308,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Three undescribed compounds, including compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    with a bicyclo[3.2.1]octane skeleton, along with a coumarin derivative (compound\n                    <jats:bold>3<\/jats:bold>\n                    ) and seven known compounds (\n                    <jats:bold>4<\/jats:bold>\n                    \u2212\n                    <jats:bold>10<\/jats:bold>\n                    ), were isolated from the heartwood of\n                    <jats:italic>Mansonia gagei<\/jats:italic>\n                    . To our knowledge, compounds\n                    <jats:bold>6<\/jats:bold>\n                    \u2013\n                    <jats:bold>8<\/jats:bold>\n                    are reported for the first time from the\n                    <jats:italic>Mansonia<\/jats:italic>\n                    genus. The structures of these compounds were determined through high\u2010resolution electrospray ionization mass spectrometry, nuclear magnetic resonance spectroscopic analysis, and density functional theory calculations. The antiviral activity of isolated compounds was assessed against dengue virus serotype DENV1, indicating that compound\n                    <jats:bold>2<\/jats:bold>\n                    exhibited potent anti\u2010dengue activity with a 50% Plaque Reduction Neutralization Test value of 17.47 \u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500951","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T22:08:28Z","timestamp":1755209308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secondary Metabolites of\n                    <i>Mansonia gagei<\/i>\n                    and Their Potential Anti\u2010dengue Properties"],"prefix":"10.1002","volume":"22","author":[{"given":"Huong Thi Thu","family":"Le","sequence":"first","affiliation":[{"name":"Department of Chemistry Ho Chi Minh City University of Education  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Hioki","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences Nagoya University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Truong Lam","family":"Tuong","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vu Thi Bich","family":"Hau","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Thu","family":"Thuy","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene and Epidemiology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Warinthorn","family":"Chavasiri","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Center of Excellence in Natural Products Chemistry Chulalongkorn University  Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kita","sequence":"additional","affiliation":[{"name":"Graduate School of Bioagricultural Sciences Nagoya University  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Kha Uyen","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Traditional Pharmacy University of Health Sciences, Vietnam National University Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh\u2010Hoa","family":"Vo","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy and Traditional Pharmacy University of Health Sciences, Vietnam National University Ho Chi Minh City  Ho Chi Minh City Vietnam"},{"name":"Research Center for Discovery and Development of Healthcare Products, VNU\u2010HCM University of Health Sciences, Vietnam National University Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9531-965X","authenticated-orcid":false,"given":"Thi\u2010Anh\u2010Tuyet","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Quality Control, University of Health Sciences Vietnam National University Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,14]]},"reference":[{"key":"e_1_2_9_2_1","article-title":"Differentiating Secondary From Primary Dengue Using IgG to IgM Ratio in Early Dengue: An Observational Hospital Based Clinico\u2010Serological Study From North India","volume":"16","author":"Changal K. 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