{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T17:33:49Z","timestamp":1784223229122,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:00:00Z","timestamp":1758931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Phoebe zhennan<\/jats:italic>\n                    S.K.Lee &amp; F.N.Wei, a rare endemic Chinese species of medicinal value, was investigated for the anti\u2010prostate cancer (anti\u2010PCa) mechanisms of its fruit\u2010derived essential oil (PZEO). This integrated study employed in vitro assays, network pharmacology, and molecular docking. Cell biology studies revealed the significant inhibitory effects of PZEO on LNCaP and PC3 tumor cells within 48\u00a0h, achieving inhibition rates of 95.1% and 91.06%, respectively. PZEO induced apoptosis in LNCaP cells at rates of 32.23% and 35.04% (0.15 and 0.2\u00a0\u00b5L\/mL). In addition, it suppressed cell migration in a time\u2010 and concentration\u2010dependent manner. Network pharmacology results revealed 465 targets of active ingredients, including 29 core targets implicated in its anti\u2010PCa efficacy. This study provides reliable data support and novel insights for developing\n                    <jats:italic>P. zhennan<\/jats:italic>\n                    fruit resources.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500952","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T18:17:40Z","timestamp":1758997060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Uncovering the Mechanism of\n                    <i>Phoebe zhennan<\/i>\n                    Essential Oil Against Prostate Cancer Based on Network Pharmacology, Molecular Docking, and In Vitro Validation"],"prefix":"10.1002","volume":"22","author":[{"given":"Xu","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Mountain Plant Resources Conservation and Germplasm Innovation for Conservation Ministry of Education College of Life Sciences\/Institute of Agricultural Bioengineering Guizhou 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