{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:08:36Z","timestamp":1787738916447,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"ABSTRACT<\/jats:title>\n \n Although fig leaves are widely used for dermatological treatment in traditional medicine, research on the bioactivity of their components is limited. In this study, an ultraviolet\u2010guided approach was employed to isolate 2 novel benzofurans (\n 1\u2013<\/jats:bold>\n 2<\/jats:bold>\n ), 12 known benzofurans (\n 3\u2013<\/jats:bold>\n 14<\/jats:bold>\n ), and 13 known coumarins (\n 15\u2013<\/jats:bold>\n 26a<\/jats:bold>\n \/\n 26b<\/jats:bold>\n ). Compounds\n 4\u2013<\/jats:bold>\n 10<\/jats:bold>\n ,\n 13\u2013<\/jats:bold>\n 14<\/jats:bold>\n ,\n 17<\/jats:bold>\n ,\n 20<\/jats:bold>\n ,\n 24<\/jats:bold>\n , and\n 26a<\/jats:bold>\n \/\n 26b<\/jats:bold>\n were detected in fig leaves for the first time. Their structures were elucidated through comprehensive spectral analysis, 1\u2010phenyl\u20103\u2010methyl\u20105\u2010pyrazolone (PMP) derivatization, and literature comparison. The absolute configurations of compounds\n 18<\/jats:bold>\n ,\n 22\u2013<\/jats:bold>\n 24<\/jats:bold>\n , and\n 26a<\/jats:bold>\n \/\n 26b<\/jats:bold>\n were determined using the Snatzke method and electronic circular dichroism analysis. Compounds\n 4<\/jats:bold>\n ,\n 6<\/jats:bold>\n , and\n 18<\/jats:bold>\n exhibited antimicrobial activity\n in vitro<\/jats:italic>\n against\n Candida albicans<\/jats:italic>\n and\n Staphylococcus aureus<\/jats:italic>\n with MIC\/MBC values ranging from 250 to 2000\u00a0\n \u00b5<\/jats:italic>\n M. Compound\n 16<\/jats:bold>\n exhibited significant melanogenic activity, yielding a relative melanin content of 147.7% (\n p<\/jats:italic>\n \u00a0<\u00a00.0001). Compounds\n 15<\/jats:bold>\n and\n 22<\/jats:bold>\n showed moderate melanogenic activity, resulting in relative melanin contents of 118.1% and 119.9% (\n p<\/jats:italic>\n \u00a0<\u00a00.05), respectively.\n <\/jats:p>","DOI":"10.1002\/cbdv.202500961","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:39:21Z","timestamp":1753119561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultraviolet\u2010Guided Isolation of Coumarins and Benzofuran Derivatives From Fig (\n Ficus carica<\/i>\n L.) Leaves and Their Bioactivities"],"prefix":"10.1002","volume":"22","author":[{"given":"Demei","family":"Chen","sequence":"first","affiliation":[{"name":"Guangzhou University of Chinese Medicine Guangzhou China"},{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Yuan","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuopeng","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deng","family":"Zang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4652-6879","authenticated-orcid":false,"given":"Haji Akber","family":"Aisa","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine Guangzhou China"},{"name":"Zhongshan Institute for Drug Discovery Shanghai Institute of Materia Medica Chinese Academy of Sciences Zhongshan China"},{"name":"State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-017-0192-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2021.06.003"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2020.04.003"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011334"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.03.044"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054910"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202300494"},{"key":"e_1_2_9_9_1","first-page":"215","article-title":"Ficus carica Linn.: A Review on Its Pharmacognostic, Phytochemical and Pharmacological Aspects","volume":"1","author":"Chawla A.","year":"2012","journal-title":"International Journal of Pharmaceutical and Phytopharmacological Research"},{"key":"e_1_2_9_10_1","first-page":"1","article-title":"Medicinal and Nutritional Analysis of Fig (Ficus carica ) Seed Oil; A New Gamma Tocopherol and Omega\u20103 Source","volume":"23","author":"Baygeldi N.","year":"2021","journal-title":"Progress in Nutrition"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2022.110237"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111393"},{"key":"e_1_2_9_13_1","article-title":"Effect of In Vitro Digestion on Anticancer and Antioxidant Activity of Phenolic Extracts From Latex of Fig Fruit (Ficus carica L.)","author":"Yeniocak S.","year":"2024","journal-title":"Chemistry and Biodiversity"},{"key":"e_1_2_9_14_1","first-page":"269","article-title":"A Review: Some Cassia and Ficus Species Used in Dermatological Diseases","volume":"13","author":"Lattupally V.","year":"2024","journal-title":"World Journal of Pharmaceutical Research"},{"key":"e_1_2_9_15_1","first-page":"137","article-title":"Medicinal Plants Traditionally Used to Treat Skin Diseases in Turkey\u2013Eczema, Psoriasis, Vitiligo","volume":"44","author":"Erarslan Z. 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