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The synthesized compounds were evaluated for their antidiabetic potential via \u03b1\u2010glucosidase and \u03b1\u2010amylase inhibition assays, as well as for antioxidant activity using 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and nitric oxide (NO) scavenging assays. Among the series, compound\n                    <jats:bold>3f<\/jats:bold>\n                    exhibited superior inhibitory activity against \u03b1\u2010glucosidase (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a035.25\u00a0\u00b5M) and \u03b1\u2010amylase (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a038.61\u00a0\u00b5M), being \u223c2.3\u2010 and \u223c2.6\u2010fold more potent, respectively, than the standard drug acarbose. In antioxidant evaluations, compound\n                    <jats:bold>3i<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a035.60\u00a0\u00b5M) demonstrated \u223c2.9\u2010fold higher activity than gallic acid in the DPPH assay, whereas\n                    <jats:bold>3d<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a030.70\u00a0\u00b5M) and\n                    <jats:bold>3a<\/jats:bold>\n                    (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a044.52\u00a0\u00b5M) showed \u223c3.8\u2010 and \u223c1.5\u2010fold higher activity in FRAP and NO scavenging assays, respectively. Molecular docking studies revealed key hydrogen bonding interactions of\n                    <jats:bold>3f<\/jats:bold>\n                    with the active site residues of both enzymes, supported by favorable docking scores. Furthermore, density functional theory (DFT) studies revealed favorable electronic and reactivity profiles, whereas ADME\/T predictions indicated good drug\u2010likeness. Overall, compound\n                    <jats:bold>3f<\/jats:bold>\n                    shows strong potential as a lead antidiabetic agent for managing postprandial hyperglycemia.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500969","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T18:09:44Z","timestamp":1756577384000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["DES\u2010Promoted Synthesis of 3,4\u2010Dihydropyrimidinones and Their Antidiabetic and Antioxidant Evaluation Supported With Computational Studies"],"prefix":"10.1002","volume":"22","author":[{"given":"Gobind","family":"Kumar","sequence":"first","affiliation":[{"name":"School of Chemistry and Physics University of KwaZulu\u2010Natal, Westville  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Mishra","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics University of KwaZulu\u2010Natal, Westville  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pule","family":"Seboletswe","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics University of KwaZulu\u2010Natal, Westville  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nontobeko","family":"Gcabashe","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics University of KwaZulu\u2010Natal, Westville  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha","family":"Gummidi","sequence":"additional","affiliation":[{"name":"School of Chemistry and Physics University of KwaZulu\u2010Natal, Westville  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Manhas","sequence":"additional","affiliation":[{"name":"Department of Chemistry, ML Sultan Campus Durban University of Technology  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talent","family":"Makhanya","sequence":"additional","affiliation":[{"name":"Department of Chemistry, ML Sultan Campus Durban University of Technology  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Bhargava","sequence":"additional","affiliation":[{"name":"Department of Chemistry I. 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