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Although pharmacological approaches targeting monoamine dysfunction have demonstrated efficacy, they are often accompanied by limitations and side effects. In this study, reserpine\u2010induced depressed mouse models were used to investigate the antidepressant potential of five essential oils (EOs) derived from\n                    <jats:italic>Jasminum sambac<\/jats:italic>\n                    (JSEOs),\n                    <jats:italic>Rosa rugosa<\/jats:italic>\n                    ,\n                    <jats:italic>Magnolia denudata<\/jats:italic>\n                    ,\n                    <jats:italic>Aloysia citriodora<\/jats:italic>\n                    (ACEOs), and\n                    <jats:italic>Abies balsamea<\/jats:italic>\n                    . The chemical compositions of the five EOs were analyzed using gas chromatography\u2010mass spectrometry (GC\u2010MS). Subsequently, experimental mice inhaled the EOs for 1 h per day, followed by behavioral assessments using the forced swim test (FST) and tail suspension test (TST). Nissl staining was employed to assess the abundance of normal neurons in the mouse brain. At the same time, immunohistochemistry (IHC), Western blot, and reverse transcription\u2010quantitative polymerase chain reaction techniques were utilized to analyze the expression of antidepressant\u2010related genes. GC\u2010MS results revealed that the primary components of the five EOs were oxygenated monoterpenes, sesquiterpene hydrocarbons, and oxygenated sesquiterpenoids. All five EOs exhibited antidepressant\u2010like effects, with JSEOs and ACEOs demonstrating the greatest antidepressant efficacy. Behavioral tests showed a reduction in immobility durations in both FST and TST. Nissl staining results indicated an increase in the number of intact neurons in the hippocampus and hypothalamus of mice following EO treatment. Furthermore, the EOs regulated the expression of crucial biomarkers, including 5\u2010hydroxytryptamine 1A receptor (5\u2010HT1A), 5\u2010HT2A, brain\u2010derived neurotrophic factor, corticotropin\u2010releasing factor, and tropomyosin\u2010related kinase B. This study underscores the potential of EO inhalation as an adjunctive therapeutic strategy for depression treatment, provides novel insights into its molecular mechanisms, and supports further exploration of natural remedies in mental health care.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500971","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T20:49:57Z","timestamp":1752266997000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antidepressant\u2010like Effects of Five Essential Oils Inhaled in Reserpine\u2010induced Depressed Mouse Models"],"prefix":"10.1002","volume":"22","author":[{"given":"Yanqing","family":"Ma","sequence":"first","affiliation":[{"name":"School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology  Guangzhou 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