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Various pharmaceutical interventions have been proposed for managing PCOS; however, the potential side effects associated with long\u2010term use and their often\u2010limited efficacy have prompted interest in complementary and alternative therapies. Recent studies indicate a growing trend toward the utilization of these alternative treatments. Medicinal herbs have historically been employed to address gynecological and infertility issues in individuals with PCOS. This study aims to systematically review the herbal remedies utilized for PCOS on a global scale. A comprehensive search was conducted across several databases, focusing on clinical trials, especially randomized controlled trials from 2010 to 2024. The findings from numerous studies suggest that a diverse array of herbal medicines may enhance various aspects of PCOS management. Certain plants are recognized as natural remedies that could positively impact different dimensions of the syndrome; nevertheless, further research is essential to elucidate their mechanisms of action and ensure their safety for long\u2010term use.<\/jats:p>","DOI":"10.1002\/cbdv.202500982","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T19:58:41Z","timestamp":1752609521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phytotherapy in Polycystic Ovary Syndrome (PCOS) Management: A Systematic Review"],"prefix":"10.1002","volume":"22","author":[{"given":"Sarah S.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anood T.","family":"Allam","sequence":"additional","affiliation":[{"name":"Clinical Pharmacy 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