{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:13:50Z","timestamp":1790716430242,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Emerging focus on cosmetic safety has propelled exploration of plant\u2010derived whitening agents.\n                    <jats:italic>Saxifraga stolonifera<\/jats:italic>\n                    , a traditional Chinese herb, was investigated for its whitening potential through its ethanol extract (\n                    <jats:italic>S. stolonifera<\/jats:italic>\n                    extract [SSE]). The main components were determined by high performance liquid chromatography (HPLC)\u2010Q\u2010TOF\u2010MS\/MS. In vitro analyses, antioxidant activity and tyrosinase (TYR) inhibition of SSE were revealed. Anti\u2010melanogenic efficacy was systematically validated using three models: B16F10 cells, zebrafish embryos, and 3D reconstructed pigmented skin model. Mechanistic studies demonstrated SSE modulates melanogenesis by targeting the mTOR complex 1 (mTORC1)\u2010TYR axis, downregulating TYR expression at mRNA\/protein levels. Molecular docking revealed the binding affinities of SSE with mTOR domain, similar to arbutin's mechanism. Consequently, these findings suggest that SSE may function as a promising natural ingredient for cosmetic formulations, offering potent skin\u2010whitening properties through melanogenesis inhibition.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202500995","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T16:35:19Z","timestamp":1751733319000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Component Analysis of\n                    <i>Saxifraga stolonifera<\/i>\n                    Extract and Its Mechanism of Melanin Inhibition"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9205-0862","authenticated-orcid":false,"given":"Yuhua","family":"Chen","sequence":"first","affiliation":[{"name":"Yunnan Botanee Bio\u2010Technology Group Co., Ltd.  Kunming China"},{"name":"Shanghai Botanee Bio\u2010Technology Group Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlang","family":"Wu","sequence":"additional","affiliation":[{"name":"Yunnan Botanee Bio\u2010Technology Group Co., Ltd.  Kunming China"},{"name":"Botanee Research Institute Shanghai Jiyan Biomedical Development Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Botanee Bio\u2010Technology Group Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Chen","sequence":"additional","affiliation":[{"name":"Botanee Research Institute Shanghai Jiyan Biomedical Development Co., Ltd.  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-218X","authenticated-orcid":false,"given":"Liping","family":"Qu","sequence":"additional","affiliation":[{"name":"Yunnan Botanee Bio\u2010Technology Group Co., Ltd.  Kunming China"},{"name":"Botanee Research Institute Shanghai Jiyan Biomedical Development Co., Ltd.  Shanghai China"},{"name":"Yunnan Characteristic Plant Extraction Laboratory Yunnan Characteristic Plant Extraction Laboratory Co., Ltd.  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2018.02.024"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.05.009"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4MD00224E"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28072981"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2005.09.009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.070"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-024-03559-z"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16120-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00808-5"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.2.151"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes11091045"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16655"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e26715"},{"key":"e_1_2_9_15_1","first-page":"970","article-title":"Simultaneous Determination of Three Stimulant Alkaloids in Kesuting Syrupy by UPLC\u2010MS\/MS","volume":"36","author":"Zhu P.","year":"2014","journal-title":"Chinese Traditional Patent Medicine"},{"key":"e_1_2_9_16_1","first-page":"343","article-title":"Anti\u2010oxidant and Anti\u2010aging Activity on Saxifraga stolonifera MEERBURGH Ethanol Extract","volume":"51","author":"Yoon M. 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