{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:24:38Z","timestamp":1790897078489,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Five new terpenoids, including one isocamphane\u2010type monoterpenoid (\n                    <jats:bold>1<\/jats:bold>\n                    ), one labdane\u2010type diterpenoid (\n                    <jats:bold>2<\/jats:bold>\n                    ), and three cadinane\u2010type sesquiterpenoids (\n                    <jats:bold>3<\/jats:bold>\n                    \u2012\n                    <jats:bold>5<\/jats:bold>\n                    ), were isolated from the whole plant of\n                    <jats:italic>Chloranthus holostegius<\/jats:italic>\n                    . A combination of spectral analysis (HR\u2010ESI\u2010MS, UV, IR, and 1D\/2D NMR), quantum chemical calculations (NMR\/ECD), and X\u2010ray crystallography were employed in the structural characterization. In anti\u2010inflammatory assays, all isolates were evaluated by examination of their inhibitory effects\u00a0on nitric oxide (NO) production in LPS\u2010stimulated RAW 264.7 cells, and compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    exhibited moderate inhibitory activity against NO release, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 21.16 \u00b1 1.37 and 18.03 \u00b1 1.24 \u00b5M, respectively.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501008","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T03:44:04Z","timestamp":1745552644000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Terpenoids from\n                    <i>Chloranthus holostegius<\/i>\n                    with Anti\u2010inflammatory Activities"],"prefix":"10.1002","volume":"22","author":[{"given":"Zhao\u2010Chun","family":"Zhan","sequence":"first","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"},{"name":"Department of Anesthesiology, Shunde Hospital Southern Medical University Foshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei\u2010Ting","family":"Weng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Xuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao\u2010Lan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Bo","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"},{"name":"School of Medicine, Guangdong Clinical Translational Center for Targeted Drug Department of Pharmacology Jinan University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1196-7850","authenticated-orcid":false,"given":"Guo\u2010Cai","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM &amp; New Drugs Research College of Pharmacy Jinan University Guangzhou P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"In Flora Reipublicae Popularis Sinicae (Zhongguo Zhiwu Zhi)","author":"Chen S. 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