{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:37:01Z","timestamp":1786977421304,"version":"build-2736575974"},"reference-count":59,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Ceriops decandra<\/jats:italic>\n                    (Griff.) Ding Hou, a mangrove species (family: Rhizophoraceae), has been traditionally used for its medicinal properties. This study investigates the phytochemical composition along with antioxidant, antimicrobial, and antidiarrheal potentials of\n                    <jats:italic>C. decandra<\/jats:italic>\n                    extracts. Successive extraction was performed using\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane, dichloromethane (DCM), ethyl\u2010acetate (EtOAc), and ethanol (EtOH). The polyphenolic profile was analyzed employing High\u2010performance liquid chromatography with diode array detection (HPLC\u2010DAD) technique. Antioxidant evaluations were performed through total phenolic, flavonoid, and tannin contents, 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH), 2,2\u2032\u2010azino\u2010bis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) (ABTS), and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    chelation assays. Antimicrobial and antidiarrheal activities were evaluated using disc diffusion and castor oil\u2010induced models, respectively. The EtOH and EtOAc extracts showed the highest phenolic (110.43\u00a0\u00b1\u00a00.0510 and 93.59\u00a0\u00b1\u00a00.0005\u00a0mg\/g), flavonoid (3.88\u00a0\u00b1\u00a00.0017 and 6.15\u00a0\u00b1\u00a00.0006\u00a0mg\/g), and tannin contents (3.65\u00a0\u00b1\u00a00.0006 and 3.99\u00a0\u00b1\u00a00.0015\u00a0mg\/g), whereas the EtOH extract exhibited strong antioxidant activity IC\n                    <jats:sub>50<\/jats:sub>\n                    : DPPH (7.08\u00a0\u00b1\u00a00.47\u00a0\u00b5g\/mL), ABTS (6.35\u00a0\u00b1\u00a00.21\u00a0\u00b5g\/mL), and Fe\n                    <jats:sup>2+<\/jats:sup>\n                    chelation (18.20\u00a0\u00b1\u00a00.66\u00a0\u00b5g\/mL). HPLC\u2010DAD analysis identified 10 polyphenolic compounds, with EtOAc extract containing the highest levels of quercetin. Antimicrobial activity of the extracts was also prominent, whereas the DCM fraction demonstrated significant antidiarrheal effect. The outcome supported the traditional use of\n                    <jats:italic>C. decandra<\/jats:italic>\n                    as a source of natural antioxidant, antimicrobial, and antidiarrheal candidate, highlighting potential pharmacological attributes.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501015","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T18:25:18Z","timestamp":1756578318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Bioactivity and Phytochemical Characterization of\n                    <i>Ceriops decandra<\/i>\n                    (Griff.) Ding Hou. Leaves: HPLC\u2010DAD Profiling, Antioxidant, Antimicrobial, and Antidiarrheal Potentials"],"prefix":"10.1002","volume":"22","author":[{"given":"Sharmin","family":"Shahjahan","sequence":"first","affiliation":[{"name":"Chemical Research Division Bangladesh Council of Scientific and Industrial Research  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3051-8348","authenticated-orcid":false,"given":"Khondoker Shahin","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Chemical Research Division Bangladesh Council of Scientific and Industrial Research  Dhaka Bangladesh"},{"name":"Institute of Food Science and Technology (IFST) Bangladesh Council of Scientific and Industrial Research (BCSIR)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayema","family":"Khanum","sequence":"additional","affiliation":[{"name":"Chemical Research Division Bangladesh Council of Scientific and Industrial Research  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjum Zerin","family":"Rupa","sequence":"additional","affiliation":[{"name":"Chemical Research Division Bangladesh Council of Scientific and Industrial Research  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nushrat Jahan","family":"Ethane","sequence":"additional","affiliation":[{"name":"Chemical Research Division Bangladesh Council of Scientific and Industrial Research  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pritam","family":"Kundu","sequence":"additional","affiliation":[{"name":"Pharmacy Discipline, Life Science School Khulna University  Khulna Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9244-5771","authenticated-orcid":false,"given":"Mst. Maya","family":"Khatun","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Division Bangladesh Council of Scientific and Industrial Research  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7271-4219","authenticated-orcid":false,"given":"Fahmida Tasnim","family":"Richi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Dhaka  Dhaka Bangladesh"},{"name":"Department of Pharmacy University of Asia Pacific  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7324-8191","authenticated-orcid":false,"given":"Md. Farhad","family":"Sarker","sequence":"additional","affiliation":[{"name":"Chemical Research Division Bangladesh Council of Scientific and Industrial Research  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1831-2278","authenticated-orcid":false,"given":"Safaet","family":"Alam","sequence":"additional","affiliation":[{"name":"Chemical Research Division Bangladesh Council of Scientific and Industrial Research  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8759-9279","authenticated-orcid":false,"given":"Md. 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