{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:45:09Z","timestamp":1788432309377,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","award":["Ref. 3.4\u2013CMR\u20131220727\u2013GF\u2010P"],"award-info":[{"award-number":["Ref. 3.4\u2013CMR\u20131220727\u2013GF\u2010P"]}],"id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A previously undescribed iboga\u2010indole alkaloid, voacamine A (\n                    <jats:bold>1<\/jats:bold>\n                    ), and the known alkaloids, voacamine (\n                    <jats:bold>2<\/jats:bold>\n                    ), voacorine (\n                    <jats:bold>3<\/jats:bold>\n                    ), and voacangine (\n                    <jats:bold>4<\/jats:bold>\n                    ) were isolated from the stem bark of\n                    <jats:italic>Voacanga africana<\/jats:italic>\n                    . The structures of the alkaloids were established by one\u2010 and two\u2010dimensional nuclear magnetic resonance analyses as well as by comparison with published data. The antiplasmodial activity of the alkaloids was assessed on a chloroquine\u2010sensitive 3D7\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    (\n                    <jats:italic>Pf3D7<\/jats:italic>\n                    ) strain, and the half\u2010maximal inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) values were determined. Alkaloids\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>3<\/jats:bold>\n                    showed good in vitro antiplasmodial activity with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 5.734 \u00b1 1.365 and 5.319 \u00b1 2.206 \u00b5g\/mL, respectively, at the concentration tested. A plausible biogenetic pathway of the bisindole alkaloids has been proposed. Protein\u2010ligand co\u2010folding was used to generate protein\u2010ligand complexes for the pfATP6 protein target and the isolated alkaloids. The stability of the modelled complexes was evaluated using molecular dynamics simulation. Scoring metrics of the generated complexes coupled to molecular mechanics generalized\u2010born solvation rescoring of the modelled ligand poses were employed to explain the antimalarial structure\u2010activity relationship for the investigated compounds. Alkaloids\n                    <jats:bold>2<\/jats:bold>\n                    and\n                    <jats:bold>3<\/jats:bold>\n                    can be considered as possible scaffolds for designing new antiplasmodial lead compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501035","type":"journal-article","created":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T19:37:09Z","timestamp":1761334629000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Iboga\u2010Indole Alkaloids as Potential Plasmodial Inhibitors: Identification, Biosynthesis, and Molecular Docking Studies"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4476-5860","authenticated-orcid":false,"given":"Smith B.","family":"Babiaka","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Science University of Buea  Buea Cameroon"},{"name":"Department of Microbial Bioactive Compounds Interfaculty Institute for Microbiology and Infection Medicine, University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7851-559X","authenticated-orcid":false,"given":"Methodius S.","family":"Lahngong","sequence":"additional","affiliation":[{"name":"Pharmacognosy Laboratory Center For Interdisciplinary Research On Medicine (CIRM), ULi\u00e9ge  Li\u00e8ge Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-6961","authenticated-orcid":false,"given":"Conrad V.","family":"Simoben","sequence":"additional","affiliation":[{"name":"Structural Genomics Consortium, University of Toronto  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4385-4271","authenticated-orcid":false,"given":"Dennis S. B.","family":"Ongarora","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Pharmaceutics and Pharmacognosy, Faculty of Health Sciences, University of Nairobi  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1484-3995","authenticated-orcid":false,"given":"Godloves F.","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science University of Buea  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieudonn\u00e9 T.","family":"Tshitenge","sequence":"additional","affiliation":[{"name":"Small Molecules, R&amp;D Crop Science  Monheim am Rhein Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1247-5754","authenticated-orcid":false,"given":"Rajshekhar","family":"Karpoormath","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6833-3299","authenticated-orcid":false,"given":"Marwaan","family":"Rylands","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Mbah","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science University of Buea  Buea Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-1439","authenticated-orcid":false,"given":"Kennedy O.","family":"Abuga","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Pharmaceutics and Pharmacognosy, Faculty of Health Sciences, University of Nairobi  Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8528-4019","authenticated-orcid":false,"given":"E. 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