{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:17:26Z","timestamp":1773494246941,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Osteoporosis, characterized by excessive osteoclast\u2010mediated bone resorption, necessitates innovative therapies to overcome the limitations of current treatments. This study explores the effects of epifriedelinol (EFD), a triterpene obtained from\n                    <jats:italic>Aster tataricus<\/jats:italic>\n                    L.fil., on RANKL\u2010induced osteoclastogenesis in RAW264.7 cells and bone marrow\u2010derived macrophages. Concentrations up to 10\u00a0\u00b5M of EFD exhibited no cytotoxicity but strongly impeded RANKL\u2010induced osteoclast differentiation, as indicated by a decrease in TRAP\u2010positive multinucleated cells in both cell types. EFD at least partially inhibited the activation of the MAPK signaling pathways (ERK, JNK, p38) and suppressed key transcription factors NFATc1 and c\u2010Fos, essential for osteoclast\u2010specific gene expression (TRAP, RANK, MMP\u20109, cathepsin K). Moreover, EFD reduced RANKL\u2010induced bone resorption in BMMs, demonstrating decreased resorption pit area in a dose\u2010dependent manner. These findings indicate that EFD inhibits osteoclast differentiation and function by targeting the MAPK\u2010mediated NFATc1\/c\u2010Fos pathway, highlighting its potential as a natural treatment for osteoclast\u2010related disorders such as osteoporosis.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501044","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:00:11Z","timestamp":1760115611000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epifriedelinol From\n                    <i>Aster tataricus<\/i>\n                    Suppresses Osteoclast Differentiation and Bone Resorption via MAPK\u2010Mediated Inhibition of NFATc1\/c\u2010Fos in RAW264.7 and BMM Cells: An In Vitro Study"],"prefix":"10.1002","volume":"22","author":[{"given":"Xiangdong","family":"Su","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Science (Shenzhen) Sun Yat\u2010sen 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