{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:24:45Z","timestamp":1780086285223,"version":"3.54.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T00:00:00Z","timestamp":1752278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100015501","name":"Qu\u1ef9 \u0110\u1ed5i m\u1edbi s\u00e1ng t\u1ea1o Vingroup","doi-asserted-by":"publisher","award":["VINIF.2024.TS.053."],"award-info":[{"award-number":["VINIF.2024.TS.053."]}],"id":[{"id":"10.13039\/501100015501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Illigera celebica Hance is an evergreen climber found in China and Southeast Asia. This study investigates the chemical composition, nitric oxide (NO) inhibitory activity, and molecular mechanisms of essential oils from I. celebica in Vietnam. Gas chromatography\u2013mass spectrometry analysis identified 20 compounds, mainly aldehydes and oxygenated sesquiterpenes. Leaf oil was dominated by dodecanal (65.9%), while khusimone (31.5%) was the major compound in stem oil. In LPS\u2010stimulated RAW 264.7 cells, the oils showed significant NO inhibition, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 26.43\u00a0\u00b1\u00a01.84\u00a0\u00b5g\/mL (leaf) and 34.41\u00a0\u00b1\u00a01.42\u00a0\u00b5g\/mL (stem). Molecular docking (AutoDock Vina 1.1.2) was performed to explore interactions between key compounds and inducible nitric oxide synthase (iNOS), cyclooxygenase\u20102 (COX\u20102), and interleukin\u20108 (IL\u20108). Dodecanal, \u03b2\u2010vetivenene, neryl isovalerate, and khusilal showed favourable binding affinities, with \u03b2\u2010vetivenene exhibiting the strongest interaction with iNOS. This is the first report on the essential oils of I. celebica, highlighting their promising natural anti\u2010inflammatory potential.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501063","type":"journal-article","created":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T21:43:40Z","timestamp":1752356620000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Chemical Composition, Anti\u2010Inflammatory Effect, and Molecular Docking of Essential Oils Extracted From\n                    <i>Illigera celebica<\/i>\n                    Hance. (Hernandiaceae)"],"prefix":"10.1002","volume":"22","author":[{"given":"Trang Huyen Xuan","family":"Hoang","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"The\u2010Huan","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4664-8972","authenticated-orcid":false,"given":"Tuan Quoc","family":"Doan","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue City Vietnam"},{"name":"Graduate School of Environmental Life, Natural Science and Technology, Okayama University  Okayama City Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5917-3243","authenticated-orcid":false,"given":"Anh Tuan","family":"Le","sequence":"additional","affiliation":[{"name":"Mien Trung Institute for Scientific Research, Vietnam Academy of Science and Technology  Hue City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0814-2401","authenticated-orcid":false,"given":"Hoai Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6566-3022","authenticated-orcid":false,"given":"Linh Thuy Thi","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Hue University of Medicine and Pharmacy Hue University  Hue City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41597-021-00997-6"},{"key":"e_1_2_9_3_1","unstructured":"\u201cIlligera Blume | Plants of the World Online | Kew Science \u201d accessed December 31 2024 http:\/\/powo.science.kew.org\/taxon\/urn:lsid:ipni.org:names."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/np9700735"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2010.12.015"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1039\/C7RA06078E"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0860-3"},{"key":"e_1_2_9_8_1","first-page":"175","volume-title":"The Alkaloids: Chemistry and Biology","author":"Conserva L. 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Kubitzki, Leaf and Stem Essential Oils by GC\u2010FID\/GC\u2010MS and 13C NMR","volume":"16","author":"Huy T.","year":"2022","journal-title":"Records of Natural Products"},{"key":"e_1_2_9_16_1","first-page":"2512","article-title":"Chemical Components of Essential Oil in the Illigera aromatica S.Z.Huang Et S.L.Mo by GC\u2010MS","volume":"17","author":"Mo S.","year":"2006","journal-title":"Lishizhen Medicine and Materia Medica Research"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2025.2486435"},{"key":"e_1_2_9_18_1","doi-asserted-by":"crossref","DOI":"10.1177\/1934578X231214159","article-title":"GC\u2010MS Characterization, In Vitro Antioxidant and Anti\u2010Inflammatory Activities of Essential Oil From the Leaves of Litsea balansae Lecomte","volume":"18","author":"Ho D. V.","year":"2023","journal-title":"Natural Products Communications"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.07.003"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2024.1369745"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29520"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2022.2026253"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2022.2132835"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1652286"},{"key":"e_1_2_9_25_1","volume-title":"Vietnamese Pharmacopoeia V","year":"2017"},{"key":"e_1_2_9_26_1","volume-title":"Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry","author":"Adams R. 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