{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:38:38Z","timestamp":1773013118496,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Medicinal plants are essential in the prevention and management of cardiovascular illnesses. This study seeks to explore the phytochemical profile and lipid\u2010lowering potential of\n                    <jats:italic>Ruta chalepensis<\/jats:italic>\n                    acetone, hexane, and aqueous extracts. Phytochemical profiling using high\u2010performance liquid chromatography revealed solvent\u2010specific variations. The aqueous extract was dominated by monoterpenes, with skimmianine (11.2%) as the major alkaloid. The acetone extracts primarily contained monoterpenes and flavonoids, with quercetin (8.2%) as a key component. The hexane extract was rich in fatty acids, with oleanolic acid (11.2%) as the predominant compound. Hyperlipidemia was induced using Triton WR\u20101339 (300\u00a0mg\/kg) in five groups, each consisting of five rats, resulting in significant elevations in total cholesterol (\n                    <jats:italic>p =<\/jats:italic>\n                    0.0008), triglycerides (\n                    <jats:italic>p =<\/jats:italic>\n                    0.0007), and low\u2010density lipoprotein\u2010cholesterol (LDL\u2010C,\n                    <jats:italic>p =<\/jats:italic>\n                    0.0003), with a reduction in high\u2010density lipoprotein\u2010cholesterol (HDL\u2010C,\n                    <jats:italic>p =<\/jats:italic>\n                    0.0215) compared to controls (analyzed by one\u2010way analysis of variance followed by Dunnett's multiple comparisons test). Treatment with\n                    <jats:italic>R. chalepensis<\/jats:italic>\n                    extracts led to notable lipid\u2010lowering effects. The acetone extract of\n                    <jats:italic>R. chalepensis<\/jats:italic>\n                    at 60\u00a0mg\/kg significantly reduced total cholesterol (81.3%) (\n                    <jats:italic>p &lt;<\/jats:italic>\n                    0.0001), triglycerides (94.5%) (\n                    <jats:italic>p &lt;<\/jats:italic>\n                    0.0001), and LDL\u2010C (85.8%) (\n                    <jats:italic>p &lt;<\/jats:italic>\n                    0.0001), while increasing HDL\u2010C by 1,160% (\n                    <jats:italic>p =<\/jats:italic>\n                    0.0003). The hexane extract showed similar effects, with reductions in TC (79.9%) (\n                    <jats:italic>p &lt;<\/jats:italic>\n                    0.0001), TGs (94.1%) (\n                    <jats:italic>p &lt;<\/jats:italic>\n                    0.0001), and LDL\u2010C (76.5%) (\n                    <jats:italic>p &lt;<\/jats:italic>\n                    0.0001) and a rise in HDL\u2010C (875.1%) (\n                    <jats:italic>p =<\/jats:italic>\n                    0.0042). The aqueous extract also lowered TC (56.6%) (\n                    <jats:italic>p =<\/jats:italic>\n                    0.0001), TGs (77.4%) (\n                    <jats:italic>p &lt;<\/jats:italic>\n                    0.0001), and LDL\u2010C (73.2%) (\n                    <jats:italic>p &lt;<\/jats:italic>\n                    0.0001) while boosting HDL\u2010C (785.1%) (\n                    <jats:italic>p =<\/jats:italic>\n                    0.0096). These results demonstrate that\n                    <jats:italic>R. chalepensis<\/jats:italic>\n                    extracts show lipid\u2010modulating properties. However, further studies and isolation of active compounds are needed to validate and clarify the findings.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501066","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T15:38:30Z","timestamp":1751384310000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Potential Lipid\u2010lowering Effects of\n                    <i>Ruta chalepensis<\/i>\n                    Aqueous, Acetone, and Hexane Extracts in Triton WR\u20101339\u2010induced Hyperlipidemia in Rats"],"prefix":"10.1002","volume":"22","author":[{"given":"Wassan","family":"Jarrar","sequence":"first","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmacy Al\u2010Zaytoonah University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-0104","authenticated-orcid":false,"given":"Arwa R.","family":"Althaher","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmacy Al\u2010Zaytoonah University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Alwahsh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmacy Al\u2010Zaytoonah University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Furqan","family":"Alkarawi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmacy Al\u2010Zaytoonah University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tariq","family":"Al\u2010Qirim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Pharmacy Al\u2010Zaytoonah University of Jordan  Amman Jordan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,1]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/0113852728295939240315040152"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.2019-0053"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-4779-6_12"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-022-00666-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsptsci.3c00234"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods12193610"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-818553-7.00011-5"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.128113"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113076"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11030592"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12112203"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/app14199017"},{"key":"e_1_2_8_14_1","first-page":"132","article-title":"Ethnopharmacological Importance of Local Flora in the Traditional Medicine of Jordan: (A Mini Review)","volume":"15","author":"Lafi Z.","year":"2022","journal-title":"Jordan"},{"key":"e_1_2_8_15_1","first-page":"792","article-title":"Evaluation of the Antidiabetic Effects of Methanolic Extracts of Neem (Azadirachta indica) Seeds on the Streptozotocin\u2010induced Wistar Rats","volume":"43","author":"Abduallah A. 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