{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:34:20Z","timestamp":1785342860558,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Seaweeds are marine macroalgae that are rich in various secondary metabolites known to exhibit different biological activities such as anti\u2010diabetic, anti\u2010inflammatory, antioxidant, etc. This study aimed to determine the bioactive metabolites, as well as the antioxidant and anti\u2010inflammatory activities of two red algae (\n                    <jats:italic>Ceramium virgatum<\/jats:italic>\n                    and\n                    <jats:italic>Gracilaria corticata<\/jats:italic>\n                    ) and two green algae (\n                    <jats:italic>Enteromorpha flexuosa<\/jats:italic>\n                    and\n                    <jats:italic>Ulva fasciata<\/jats:italic>\n                    ), which are prevalent in the coastal region of the Bay of Bengal. The total phenolic and flavonoid contents were determined using the Folin\u2013Ciocalteu and aluminium chloride methods. Antioxidant and anti\u2010inflammatory activities were evaluated using the ABTS assay and protein denaturation, LPS\u2010induced RAW264.7 cells, respectively. The highest total phenolic (5.73\u00a0\u00b1\u00a00.06\u00a0mg GAE\/g dry extract) and flavonoid (5.25\u00a0\u00b1\u00a001.6\u00a0mg QE\/g dry extract) contents were found in\n                    <jats:italic>C. virgatum<\/jats:italic>\n                    , and it also shows good antioxidant activity with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 258.66\u00a0\u00b5g\/mL. The protein denaturation assay and NO production inhibition assay of\n                    <jats:italic>C. virgatum<\/jats:italic>\n                    showed the lowest IC\n                    <jats:sub>50<\/jats:sub>\n                    value (65.39\u00a0\u00b5g\/mL) and lower NO level. Analysis of secondary metabolites using HR\u2010LCMS reveals the presence of 12 phytoconstituents in\n                    <jats:italic>C. virgatum<\/jats:italic>\n                    extract. From these results, it is evident that C\n                    <jats:italic>. virgatum<\/jats:italic>\n                    can contribute to the development of antioxidant and anti\u2010inflammatory agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501094","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T20:10:51Z","timestamp":1757362251000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In Vitro Antioxidant and Anti\u2010Inflammatory Activities of Seaweeds From the Bay of Bengal Coastal Region in Lipopolysaccharide\u2010Induced RAW264.7 Cells"],"prefix":"10.1002","volume":"22","author":[{"given":"Parthasarathi","family":"Perumal","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology Greensmed Labs  Chennai Tamil Nadu 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