{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:38:49Z","timestamp":1773013129111,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Cordyceps militaris<\/jats:italic>\n                    is a medicinal fungus known for its immunomodulatory effects. This study compared the antioxidant and anti\u2010inflammatory activities of an albino strain (\n                    <jats:italic>C. militaris<\/jats:italic>\n                    SHBTQ) and its wild\u2010type counterpart (SHQ) using ethanol extracts from their fruiting bodies. The albino strain exhibited significantly higher bioactive compound levels, with cordycepin and pentostatin concentrations 2.37\u2010 and 1.74\u2010fold higher than in the wild type. Enhanced polyphenol and flavonoid content correlated with stronger 1,1\u2010diphenyl\u20102\u2010picrylhydrazyl and azino\u2010bis\u2010(3\u2010ethylbenzothiazoline sulfonate) radical scavenging (2.67\u2010 and 1.91\u2010fold higher) and superior copper\u2010chelating ability (97.52% vs. 51.83% at 5 mg\/L). It also demonstrated greater anti\u2010inflammatory effects, with a lower 50% inhibitory concentration in the bovine serum albumin denaturation assay (7.42 vs. 14.49 mg\/mL) and reduced oxidative stress in zebrafish models. The superior bioactivity of SHBTQ, likely due to its high bioactive compound content, underscores its therapeutic potential against oxidative stress\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501100","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T13:50:19Z","timestamp":1751032219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhanced Antioxidant and Anti\u2010inflammatory Properties of Albino\n                    <i>Cordyceps militaris<\/i>\n                    : A Comparative Study With Wild\u2010type Strain"],"prefix":"10.1002","volume":"22","author":[{"given":"Tao Xuan","family":"Vu","sequence":"first","affiliation":[{"name":"Center for Experimental Biology National Center for Technological Progress Ministry of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh\u2010Trung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Natural Science and Technology Tay Nguyen University  Buon Ma Thuot City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anh Ngoc","family":"Dao","sequence":"additional","affiliation":[{"name":"Center for Experimental Biology National Center for Technological Progress Ministry of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tram Bao","family":"Tran","sequence":"additional","affiliation":[{"name":"Center for Experimental Biology National Center for Technological Progress Ministry of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen Thi Hoang","family":"Le","sequence":"additional","affiliation":[{"name":"Center for Experimental Biology National Center for Technological Progress Ministry of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van\u2010Tuan","family":"Tran","sequence":"additional","affiliation":[{"name":"VNU\u2010HUS Strong Research Group on Biotechnology of Filamentous Fungi and Medicinal Mushrooms (BFG) University of Science, Vietnam National University  Hanoi Vietnam"},{"name":"Faculty of Biology University of Science Vietnam National University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thu\u2010Huong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Faculty of Basic Medicine Hanoi University of Public Health  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2584-1466","authenticated-orcid":false,"given":"Quang\u2010Vinh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology and Environment Tay Nguyen University  Buon Ma Thuot City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2024.10.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-012-1005-6"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2011-12-11-r116"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2017.09.001"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-024-03833-8"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-58742-z"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12917-024-04338-8"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jobm.202400409"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3273"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2012.09.003"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.110711"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1850352"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.4014\/jmb.1701.01043"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1660967"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000500164"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737140.4.1.27"},{"key":"e_1_2_9_14_1","first-page":"36","article-title":"Chemical composition analysis of cultured Cordyceps militaris","volume":"34","author":"Chen C.","year":"2013","journal-title":"Food Science"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.01237"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1153153"},{"key":"e_1_2_9_17_1","first-page":"585","article-title":"Analysis of active components and antioxidant activity of albino Cordyceps militaris","volume":"39","author":"Zhang XiWen Z. 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