{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:43:51Z","timestamp":1790714631127,"version":"4.1.0"},"reference-count":72,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The new Schiff base ligand\n                    <jats:italic>N<\/jats:italic>\n                    ,\n                    <jats:italic>N<\/jats:italic>\n                    \u2032\u2010thiophene\u2010(bis\u20101\u2010ethyl\u20106,8\u2010difluoro\u20107\u2010(3\u2010methylpiperazin\u20101\u2010yl)\u20104\u2010oxo\u20101,4\u2010dihydroquinoline\u20103\u2010carboxylic acid) (H\n                    <jats:sub>2<\/jats:sub>\n                    L) was synthesized via condensation of thiophene\u20102,5\u2010diamine with lomefloxacin in ethanol using glacial acetic acid. H\n                    <jats:sub>2<\/jats:sub>\n                    L reacted as tetradentate ligand with chromium(III), manganese(II), and cobalt(II). The synthesized compounds were characterized using elemental analysis, molar conductivity (\u039b\n                    <jats:sub>m<\/jats:sub>\n                    ), magnetic susceptibility (\n                    <jats:italic>\u00b5<\/jats:italic>\n                    <jats:sub>eff<\/jats:sub>\n                    ), FTIR, UV\u2013Vis, GC\u2013MS, and thermal studies were employed to ensure the chelation process. Infrared measurements confirmed that H\n                    <jats:sub>2<\/jats:sub>\n                    L chelated with metal ions via the carboxylate oxygen and nitrogen of the azomethine group also, with water molecules. UV\u2013Vis and magnetic moment data supported octahedral geometries for all complexes. The calculated optical band gap energy (\n                    <jats:italic>E<\/jats:italic>\n                    <jats:sub>g<\/jats:sub>\n                    ) values suggested that our complexes were more electro\u2010conductive relative to H\n                    <jats:sub>2<\/jats:sub>\n                    L. Thermal analyses revealed the presence of significant lattice and coordinated water molecules within the complexes' coordination spheres. Thermodynamic parameters including activation energy, entropy change, enthalpy change, and Gibbs free energy change were derived using Coats\u2013Redfern and Horowitz\u2013Metzger methods. Disc diffusion method was implemented for assessing antimicrobial effects versus some pathogenic microorganisms. The data revealed that Cr(III) complex as most effective against\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . Cytotoxicity tests on normal prostate epithelial cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a06.30\u201310.43\u00a0\u00b5M) indicated significant toxicity and limited selectivity, restricting anticancer applicability.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501117","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T18:14:33Z","timestamp":1758564873000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["First Report on some N\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    \u2010Donor Sets Tetradentate Schiff Base and Its Metal Complexes: Characterization and Antimicrobial Investigation"],"prefix":"10.1002","volume":"22","author":[{"given":"Amira A.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Basic Science Zagazig Higher Institute of Engineering and Technology  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed S.","family":"El\u2010Gedamy","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry and Molecular biology Urology and Nephrology Center  Mansoura Egypt"},{"name":"Department of Medical Laboratories Technology, College of Health and Medical Technologies Al\u2010Ayen Iraqi University (AUIQ), An Nasiriyah  Thi\u2010Qar Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadeek A.","family":"Sadeek","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Zagazig University  Zagazig Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6018-7319","authenticated-orcid":false,"given":"Hazem S.","family":"Elshafie","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Forestry, Food and Environmental Sciences 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