{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:42:20Z","timestamp":1778794940147,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mandacaru (\n                    <jats:italic>Cereus jamacaru<\/jats:italic>\n                    DC.) is a species of treelike cactus typical of the arid and semiarid regions of northeastern Brazil. Initially, the ethanol extract of mandacaru succulent and segmented stems was obtained and then submitted to liquid\u2010liquid partition with hexane, dichloromethane, and ethyl acetate. The obtained fractions were evaluated for their cytotoxic potential against HCT\u2010116 cells (colorectal carcinoma), with the hexane (88.59 \u00b1 10.88%) and dichloromethane (65.91 \u00b1 14.03%) fractions being the most active ones. These fractions were further submitted to chromatography on silica (63\u2013200\u00a0\u00b5m), pore diameter 60 \u00c5, resulting in several subfractions that were re\u2010analyzed for cytotoxic activity. Furthermore, the bioactive subfractions were analysed by gas chromatography coupled with mass spectrometry. Arithmetic indexes and molecular networks (Global Natural Products Social Molecular Networking [GNPS]) were employed to establish the chemical profile. Thereby, it was possible to annotate 57 compounds, including terpenes, esters, alcohols, alkanes, fatty acids, and derivatives, of which 27 compounds were also annotated by the GNPS platform.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501125","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T19:04:30Z","timestamp":1752779070000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of Cytotoxic Potential and Chemical Fingerprinting of Mandacaru (\n                    <i>Cereus jamacaru<\/i>\n                    ) Bioactive Fractions"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9071-4423","authenticated-orcid":false,"given":"Luiz Henrique Sales","family":"de Menezes","sequence":"first","affiliation":[{"name":"Nucleus of Research on Bioactive Compounds Institute of Chemistry, Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2036-7171","authenticated-orcid":false,"given":"G\u00e1veni Barbosa","family":"Val\u00e9rio","sequence":"additional","affiliation":[{"name":"Nucleus of Research on Bioactive Compounds Institute of Chemistry, Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4138-8040","authenticated-orcid":false,"given":"Paula Rezende","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Post\u2010graduation Program in Health Sciences Santo Amaro University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6524-3343","authenticated-orcid":false,"given":"Arlene Bispo","family":"dos Santos Nossol","sequence":"additional","affiliation":[{"name":"Laboratory of Nanobiotechnology Professor Dr. Luiz Ricardo Goulart Filho Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-5153","authenticated-orcid":false,"given":"Leticia Veras","family":"Costa\u2010Lotufo","sequence":"additional","affiliation":[{"name":"Marine Natural Products Pharmacology Laboratory Institute of Biomedical Sciences, University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1564-9107","authenticated-orcid":false,"given":"Marcos","family":"Pivatto","sequence":"additional","affiliation":[{"name":"Nucleus of Research on Bioactive Compounds Institute of Chemistry, Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5436-8316","authenticated-orcid":false,"given":"Amanda","family":"Danuello","sequence":"additional","affiliation":[{"name":"Nucleus of Research on Bioactive Compounds Institute of Chemistry, Federal University of Uberl\u00e2ndia  Uberl\u00e2ndia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.174875"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112423"},{"key":"e_1_2_9_4_1","first-page":"1997","article-title":"Antitumor Effects of Curcumin on the Proliferation, Migration, and Apoptosis of human Colorectal Carcinoma HCT\u2010116 Cells","volume":"44","author":"Xiang L.","year":"2020","journal-title":"Oncology Reports"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjac.2023.100270"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2022.108987"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27154989"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbi.2021.102141"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2015.08.001"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.9b01285"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.01.021"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aspen.2023.102051"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjm.2017.09.007"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2019.02.033"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.08.004"},{"key":"e_1_2_9_16_1","volume-title":"\u00c1rvores Brasileiras. 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