{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:04:16Z","timestamp":1773493456457,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T00:00:00Z","timestamp":1754524800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","award":["2308085MC68"],"award-info":[{"award-number":["2308085MC68"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Dendrobium<\/jats:italic>\n                    \u2010derived actinomycetes represent a promising source of bioactive natural products with potential applications in pharmaceutical chemistry. In this study, a rhizosphere soil\u2010derived actinomycete strain,\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    sp. AHMU XC001, isolated from\n                    <jats:italic>Dendrobium huoshanense<\/jats:italic>\n                    , displayed moderate neuroprotective activity and was selected for further secondary metabolite isolation. Bioassay\u2010guided fractionation of the crude extract led to the discovery of two new compounds, designated strepisocoumarins A and B (\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    ), along with two known analogs, 6,8\u2010dihydroxy\u20103\u2010methylisocoumarin (\n                    <jats:bold>3<\/jats:bold>\n                    ) and 6,8\u2010dihydroxy\u20103\u2010hydroxymethyl\u2010isocoumarin (\n                    <jats:bold>4<\/jats:bold>\n                    ). Their structures were elucidated by comprehensive nuclear magnetic resonance spectroscopic and mass spectrometric analyses. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    were characterized as 5\u20105' and 5\u20107' heterodimers of compounds\n                    <jats:bold>3<\/jats:bold>\n                    and\n                    <jats:bold>4<\/jats:bold>\n                    , respectively. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2212\n                    <jats:bold>4<\/jats:bold>\n                    showed no antimicrobial activity against\n                    <jats:italic>Bacillus subtilis<\/jats:italic>\n                    1064,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ATCC 29213, MRSA 669, and\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    ATCC 19606. Furthermore, they exhibited no cytotoxic effects on various human cancer cell lines, including CNE2, MCF\u20107, HepG2, and ECA109. Notably, compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2212\n                    <jats:bold>4<\/jats:bold>\n                    effectively inhibited A\u03b21\u201042\u2010induced reduction in cell viability and alleviated cytotoxicity in the human neuroblastoma SH\u2010SY5Y cell line. These findings pave the way for further investigation of compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2212\n                    <jats:bold>4<\/jats:bold>\n                    as potential lead molecules for the development of neuroprotective agents targeting Alzheimer\u2032s disease.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501134","type":"journal-article","created":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T20:10:08Z","timestamp":1754597408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of Two New Neuroprotective Isocoumarin Dimers From the\n                    <i>Dendrobium huoshanense<\/i>\n                    \u2010derived\n                    <i>Streptomyces<\/i>\n                    sp. AHMU XC001"],"prefix":"10.1002","volume":"22","author":[{"given":"Wenjuan","family":"Ding","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Biotechnology for Microbial Drugs State Key Laboratory of Bioactive Substance &amp; Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunya","family":"Xie","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Biotechnology for Microbial Drugs State Key Laboratory of Bioactive Substance &amp; Function of Natural Medicines, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing P. R. China"},{"name":"School of Life Sciences Anhui Medical University  Hefei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Medical University  Hefei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaozhuang","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Medical University  Hefei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Medical University  Hefei P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyao","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Medical University  Hefei P. R. China"},{"name":"School of Medicine and Health Fangchenggang Vocational Technical College Fangchenggang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunchang","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biodiversity Conservation and Bioresource Utilization of Jiangxi Province College of Life Sciences Jiangxi Normal University  Nanchang P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0532-7390","authenticated-orcid":false,"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Life Sciences Anhui Medical University  Hefei P. R. 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