{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:57:25Z","timestamp":1755226645514,"version":"3.43.0"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Five previously unreported <jats:italic>N<\/jats:italic>\u2010methyl\u20104\u2010hydroxy\u20103,5\u2010disubstituted\u20102\u2010pyridinone analogues, funiculosins B\u2013F (<jats:bold>1<\/jats:bold>\u2013<jats:bold>5<\/jats:bold>), along with the known compound funiculosin (<jats:bold>6<\/jats:bold>) were isolated by bioassay\u2010guided fractionation from <jats:italic>Talaromyces cecidicola<\/jats:italic> J\u20104. Their structures were established by extensive spectroscopic analysis. The absolute configurations were tentatively assigned based on biogenetic considerations and electronic circular dichroism calculations. The availability of these compounds enabled a subsequent small antifungal structure\u2212activity relationship study that revealed tetrahydroxycyclopentyl substitution as a key modulator of bioactivity. Compounds <jats:bold>3<\/jats:bold> and <jats:bold>6<\/jats:bold> exhibited pronounced inhibitory activity against human pathogenic fungi <jats:italic>Cryptococcus neoformans<\/jats:italic> and <jats:italic>Candida albicans<\/jats:italic> with MIC values of 3.13 and 12.5 \u00b5g\/mL, respectively. Moderate activity was observed with <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> against <jats:italic>C. neoformanse<\/jats:italic> and <jats:italic>C. albicans<\/jats:italic>, whereas <jats:bold>4<\/jats:bold> and <jats:bold>5<\/jats:bold> showed only negligible antifungal activity.<\/jats:p>","DOI":"10.1002\/cbdv.202501154","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T04:27:56Z","timestamp":1744777676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Funiculosins B\u2013F, Five Undescribed Pyridinone Derivatives Isolated From the Fungus <i>Talaromyces cecidicola<\/i> J\u20104"],"prefix":"10.1002","author":[{"given":"Leilei","family":"Fu","sequence":"first","affiliation":[{"name":"Ocean College, Zhejiang University  Zhoushan 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