{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:19:10Z","timestamp":1787793550873,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T00:00:00Z","timestamp":1760745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Taraxacum farinosum<\/jats:italic>\n                    and\n                    <jats:italic>Taraxacum mirabile<\/jats:italic>\n                    are endemic species traditionally used to treat diabetes. This study investigated the antidiabetic, antioxidant, and phytochemical properties of methanol extracts of aerial and root parts of both species and sub\u2010extracts (\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexane, dichloromethane, ethyl acetate,\n                    <jats:italic>n<\/jats:italic>\n                    \u2010butanol, and water) derived from the active\n                    <jats:italic>T. farinosum<\/jats:italic>\n                    methanol extract. Enzyme inhibition assays revealed that the methanol extract (TFA) and ethyl acetate sub\u2010extract (TFAEA) of\n                    <jats:italic>T. farinosum<\/jats:italic>\n                    showed superior \u03b1\u2010amylase inhibition compared to the standard drug acarbose. In contrast, moderate inhibition was observed against \u03b1\u2010glucosidase. The same extracts also demonstrated high total phenolic and flavonoid contents and exhibited vigorous radical scavenging activity in DPPH, 2,2\u2032\u2010azinobis(3\u2010ethylbenzothiazoline\u20106\u2010sulfonic acid) diammonium salt (ABTS), and FRAP assays. In cell line studies, the extracts showed a noncytotoxic effect at 1000\u00a0\u00b5g\/mL on \u03b2\u2010TC6 cell proliferation and enhanced insulin secretion in a glucose concentration\u2010dependent manner (0\u201325\u00a0mM). LC\u2013HRMS analysis identified ferulic acid as the major compound, along with luteoloside and liquiritigenin, which may contribute to the observed bioactivities. These results suggest that\n                    <jats:italic>T. farinosum<\/jats:italic>\n                    possesses multifaceted antidiabetic potential through enzyme inhibition, \u03b2\u2010cell stimulation, and antioxidant mechanisms, supporting its traditional use and highlighting its potential for further pharmacological development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501160","type":"journal-article","created":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T17:53:29Z","timestamp":1760810009000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Antidiabetic Mechanisms of\n                    <i>Taraxacum farinosum<\/i>\n                    and\n                    <i>Taraxacum mirabile<\/i>\n                    Extracts: Enzyme Inhibition, Insulin Secretion, and LC\u2013HRMS\u2010Based Phytochemical Analysis"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3860-7222","authenticated-orcid":false,"given":"Leyla","family":"Pa\u015fayeva","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4689-0657","authenticated-orcid":false,"given":"Ay\u015fe K\u00fcbra","family":"Karabo\u011fa Arslan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7123-8396","authenticated-orcid":false,"given":"Hanifa","family":"Fatullayev","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra K\u00f6ng\u00fcl","family":"\u015eafak","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osman","family":"Tugay","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy Sel\u00e7uk University  Konya T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00fckerrem Bet\u00fcl","family":"Yerer","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy Erciyes University  Kayseri T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.26650\/JARHS2020-670992","article-title":"Taraxacum farinosum Hausskn. & Bornm. Bitkisinin Antioksidan Aktivite Y\u00f6n\u00fcnden Incelenmesi","volume":"3","author":"Sar\u0131 A.","year":"2020","journal-title":"Sa\u011fl\u0131k Bilimlerinde \u0130leri Ara\u015ft\u0131rmalar Dergisi"},{"key":"e_1_2_10_3_1","first-page":"788","article-title":"Taraxacum Wiggers","volume":"5","author":"Van Soest J.","year":"1975","journal-title":"Flora of Turkey and the East Aegean Islands"},{"key":"e_1_2_10_4_1","volume-title":"T\u00fcrkiye bitkileri listesi: (Damarl\u0131 Bitkiler)","author":"G\u00fcner A.","year":"2012"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.611652"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.regen.2021.100048"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2024.117695"},{"key":"e_1_2_10_8_1","article-title":"An Overview of Therapeutic Potentials of Taraxacum officinale (Dandelion): A Traditionally Valuable Herb With a Reach Historical Background","volume":"7","author":"Jalili C.","year":"2020","journal-title":"World Cancer Research Journal"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hermed.2017.04.002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.2176"},{"key":"e_1_2_10_11_1","first-page":"421","article-title":"Effect of Taraxacum officinale Leaf Extract on Liver Antioxidant Status in Streptozotocin\u2010Induced Diabetic Male Wistar Rats","volume":"23","author":"Nzekwe S.","year":"2020","journal-title":"African Journal of Biomedical Research"},{"key":"e_1_2_10_12_1","first-page":"387","article-title":"Investigating the Effect of Taraxacum officinale L. 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