{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T13:45:30Z","timestamp":1782913530424,"version":"3.54.5"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T00:00:00Z","timestamp":1753056000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Scutellariae Radix comprises two specifications: Zi Qin (ZQ) and Ku Qin (KQ). Traditionally, ZQ preferentially clears large intestine heat, whereas KQ targets lung and stomach heat. Both function as ministerial components in Da\u2010Chai\u2010Hu\u2010Tang (DCHT) for intestinal and inflammatory diseases, but pharmacological differences remain unclear. Using a rat model of large intestine damp\u2010heat syndrome, this study compared the effects of ZQ, KQ, and their DCHT combinations (ZQ\u2010DCHT, KQ\u2010DCHT). Treatments significantly reduced body temperature, normalized thymus and spleen index (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), and alleviated ileum and colon pathology. Levels of interleukin\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , interleukin\u20102, interleukin\u20106, interleukin\u201010, and secretory immunoglobulin A were reduced significantly (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.05), with ZQ\/ZQ\u2010DCHT exhibiting greater efficacy than KQ\/KQ\u2010DCHT at equivalent doses. This correlated with ZQ's higher baicalin (17.76%\u00a0vs. 14.64%) and lower wogonin (0.21%\u00a0vs. 0.35%) than KQ. Network pharmacology analysis suggested components might act through the Janus kinase 2\/signal transducer and activator of transcription 3 (JAK2\/STAT3) pathway. All treatments suppressed colonic phosphorylated STAT3 (p\u2010STAT3) expression, with ZQ\/ZQ\u2010DCHT demonstrating higher inhibition than KQ\/KQ\u2010DCHT (excluding low\u2010dose groups). These results indicated enhanced effects of ZQ\/ZQ\u2010DCHT in reducing immune\u2010inflammatory markers. The efficacy might be attributed to baicalin, which modulated the colonic immune response by inhibiting p\u2010STAT3 expression, leading to alleviation of inflammatory reactions.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501198","type":"journal-article","created":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T17:34:02Z","timestamp":1753119242000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Study on the Specifications of Scutellariae Radix in Da\u2010Chai\u2010Hu\u2010Tang Based on Efficacy in a Rat Model of Large Intestine Damp\u2010Heat Syndrome and Chemical Composition Differences"],"prefix":"10.1002","volume":"22","author":[{"given":"Weixian","family":"Shao","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing P. R. 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