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BCXT\u201022.1, was investigated, leading to the isolation and structural elucidation of 10 secondary metabolites, including two new compounds, polyporusterone H (\n                    <jats:bold>1<\/jats:bold>\n                    ) and stellatinol A (\n                    <jats:bold>4<\/jats:bold>\n                    ), along with eight known compounds, panuosterone (\n                    <jats:bold>2<\/jats:bold>\n                    ), makisterone A (\n                    <jats:bold>3<\/jats:bold>\n                    ), stellatin (\n                    <jats:bold>5<\/jats:bold>\n                    ), embeurekol C (\n                    <jats:bold>6<\/jats:bold>\n                    ), oxepinamide D (\n                    <jats:bold>7<\/jats:bold>\n                    ), oxepinamide F (\n                    <jats:bold>8<\/jats:bold>\n                    ), oxepinamide J (\n                    <jats:bold>9<\/jats:bold>\n                    ), and protubonine B (\n                    <jats:bold>10<\/jats:bold>\n                    ). All of the isolated compounds, except for\n                    <jats:bold>8<\/jats:bold>\n                    , showed cytotoxicity toward both MCF\u20107 and SK\u2010Mel\u20102 cell lines, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 65.38\u00a0\u00b1\u00a01.17 to 94.20\u00a0\u00b1\u00a03.41\u00a0\u00b5M. Compound\n                    <jats:bold>1<\/jats:bold>\n                    additionally displayed cytotoxicity toward HepG2 cells (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a087.65\u00a0\u00b1\u00a03.49\u00a0\u00b5M), while exhibiting no cytotoxicity toward the normal human embryonic kidney cell line\u2010293A (HEK\u2010293A) cell line. Besides, compounds\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    weakly inhibited nitric oxide (NO) overproduction in lipopolysaccharide (LPS)\u2010stimulated BV2 cells, with inhibition rates of 36.6%\u00a0\u00b1\u00a01.3% and 31.7%\u00a0\u00b1\u00a02.9% at 40\u00a0\u00b5M, respectively. Molecular docking simulations suggested that\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    may exert their NO inhibitory effects by interacting with the active site of the inducible nitric oxide synthase (iNOS) protein, thereby modulating its activity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501213","type":"journal-article","created":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T18:54:35Z","timestamp":1753469675000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ecdysteroids, Phenolics, and Alkaloids From a Mangrove\u2010Derived Fungus\n                    <i>Aspergillus<\/i>\n                    sp. BCXT\u201022.1 With Cytotoxic and NO Inhibitory Activities"],"prefix":"10.1002","volume":"22","author":[{"given":"Dang Viet","family":"Anh","sequence":"first","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"},{"name":"Graduate University of Science and Technology, VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Le Thi","family":"Vien","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pham Thi","family":"Cham","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Hoang","family":"Nam","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Quoc","family":"Vuong","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi Thanh","family":"Ngan","sequence":"additional","affiliation":[{"name":"Institute of Biology VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Do Thi","family":"Thao","sequence":"additional","affiliation":[{"name":"Institute of Biology VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Sung","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy Chosun University  Gwangju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Hong","family":"Quang","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Vietnam Academy of Science and Technology (VAST)  Hanoi Vietnam"},{"name":"Graduate University of Science and Technology, VAST  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2020.1789063"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21501203.2013.785448"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/md22080372"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00041A"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00343-009-9138-7"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.15406\/japlr.2019.08.00305"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1405821"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27238369"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/md10051081"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2013.04.031"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2024.134414"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.202402986"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA01359A"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.47.1626"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2022.113511"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/arch.20329"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.40.143"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10286020.2010.544654"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-3-8"},{"key":"e_1_2_9_21_1","unstructured":"M. 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