{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:40:25Z","timestamp":1773013225789,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T00:00:00Z","timestamp":1750377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Three new sesquiterpenoid dimers linderasesquiterpenoids A\u2013C (\n                    <jats:bold>1\u20133<\/jats:bold>\n                    ) and three known compounds\n                    <jats:bold>4\u20136<\/jats:bold>\n                    were co\u2010isolated from the\n                    <jats:italic>Lindera glauca<\/jats:italic>\n                    . Their structures were elucidated based on spectroscopic methods and electronic circular dichroism calculations. Among them, linderasesquiterpenoid A (\n                    <jats:bold>1<\/jats:bold>\n                    ) featuring the rare [4, 9] ring system was the first example of sesquiterpenoid dimers, and also the sesquiterpenoid dimers components were first found in this plant. Meanwhile, linderasesquiterpenoid A (\n                    <jats:bold>1<\/jats:bold>\n                    ) exhibited stronger anti\u2010inflammatory activity against lipopolysaccharide\u2010induced nitric oxide (NO) production in RAW 264.7 cells with a 50% inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) value of 11.0 \u00b5M than positive control (indomethacin, IC\n                    <jats:sub>50<\/jats:sub>\n                    24.1 \u00b5M). Further studies demonstrated that linderasesquiterpenoids A (\n                    <jats:bold>1<\/jats:bold>\n                    ) significantly suppressed the protein expression of the enzyme inducible NO synthase, but did not affect the enzyme cyclooxygenase\u20102.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501246","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T11:30:16Z","timestamp":1750419016000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New Bis\u2010sesquiterpenoids From the\n                    <i>Lindera glauca<\/i>\n                    With Anti\u2010inflammatory Activity by Inhibiting the Lipopolysaccharide\u2010induced Expression of Inducible Nitric Oxide Synthase"],"prefix":"10.1002","volume":"22","author":[{"given":"Binglin","family":"Chang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zelin","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingnan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingming","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxin","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yena","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat\u2010Sen University Cancer Center  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-016X","authenticated-orcid":false,"given":"Hui","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.05.026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2017.07.016"},{"key":"e_1_2_8_4_1","first-page":"853","article-title":"Terpenes From Lindera glauca","volume":"11","author":"Komae H.","year":"1972","journal-title":"Phytochemistry"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(95)00399-R"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107135"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0838-1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104871"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c14-00381"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2022.105199"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9CC09159A"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.2c01364"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10575639708043753"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-969564"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00300a047"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105111"}],"container-title":["Chemistry &amp; 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