{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:42Z","timestamp":1785484902850,"version":"3.56.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Tripterygium wilfordii<\/jats:italic>\n                    Hook. f. (LGT) is commonly used in the treatment of rheumatoid arthritis, but its clinical application is limited by severe hepatotoxicity. Proper compatibility contributes to toxicity reduction and efficacy enhancement.\n                    <jats:italic>Chinese Materia Medica<\/jats:italic>\n                    textbooks record that compatibility with\n                    <jats:italic>Spatholobus suberectus<\/jats:italic>\n                    Dunn (JXT) can prevent the adverse effects of LGT. Nevertheless, the detoxification effect and underlying mechanism of compatibility with JXT in LGT\u2010induced hepatotoxicity are still unclear. First, the detoxification effect of JXT was evaluated through serum biochemical indicators and liver histopathology. Additionally, the attenuation mechanism was elucidated. The anti\u2010inflammatory and analgesic efficacy of LGT, after compatibility with JXT, was evaluated. Moreover, the main toxic component triptolide (TP) of LGT and the main active components of JXT were detected by high\u2010performance liquid chromatography (HPLC). Our findings revealed that compatibility with JXT significantly reduced serum levels of biochemical indicators and alleviated histopathological damage. Notably, the mRNA and protein expression levels of vascular endothelial growth factor A (VEGFA) and Flt\u20101 were significantly downregulated. Moreover, compatibility with JXT enhanced the anti\u2010inflammatory and analgesic efficacy of LGT, while also reducing TP content. In conclusion, compatibility with JXT reduced LGT\u2010induced hepatotoxicity and potentiated its anti\u2010inflammatory and analgesic efficacy. The underlying attenuation mechanism might involve inhibiting VEGFA\/Flt\u20101 signaling and reducing TP content.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501256","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T17:25:31Z","timestamp":1763400331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Discovery in Compatibility of Traditional Chinese Medicine:\n                    <i>Spatholobus suberectus<\/i>\n                    Dunn Suppresses\n                    <i>Tripterygium wilfordii<\/i>\n                    Hook. f.\u2010Induced Main Toxicity and Enhances Its Main Efficacy"],"prefix":"10.1002","volume":"23","author":[{"given":"Lijie","family":"Ji","sequence":"first","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Song","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming zhu","family":"Gong","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianzhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenjie","family":"Du","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingwen","family":"He","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0014-551X","authenticated-orcid":false,"given":"Junming","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Henan University of Chinese Medicine  Zhengzhou China"},{"name":"Co\u2010Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan &amp; Education Ministry of P. 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