{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:14:18Z","timestamp":1773494058428,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Edible bird's nest (EBN) has been used in the treatment of pharyngitis, sore throat, and excessive sputum. The current study investigated the therapeutic efficacy and mechanisms of EBN against acute pharyngitis (AP). Peptides, amino acids, fatty acids, carbohydrate derivatives, and purine nucleosides were identified tentatively in EBN through the LC\u2013MS method. The animal experiments showed that EBN mitigated AP via reducing the pathological state of pharyngeal tissue, downregulating the serum levels of PGE2 and IL\u20101\u03b2, and inhibiting the NF\u2010\u03baB signaling pathway in the AP rat model. Moreover, EBN also displayed the analgesic effect by decreasing the number of writhing and the serum PGE2 level in vivo. In addition, EBN exerted the expectorant activity through increasing phenol red secretion and inhibiting the expression of MUC5AC and MUC5B in the pharynx of AP model rats. This study suggests that EBN could alleviate AP through its anti\u2010inflammation as well as its effects against the symptoms of sore throat and excessive sputum.<\/jats:p>","DOI":"10.1002\/cbdv.202501260","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T19:34:47Z","timestamp":1754940887000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Edible Bird's Nest Ameliorated Acute Pharyngitis Through Exerting the Anti\u2010Inflammatory, Analgesic, and Expectorant Efficacy"],"prefix":"10.1002","volume":"22","author":[{"given":"Qingya","family":"Sun","sequence":"first","affiliation":[{"name":"College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin People's Republic of China"},{"name":"Tianjin International Joint Academy of Biomedicine  Tianjin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin People's Republic of China"},{"name":"Tianjin International Joint Academy of Biomedicine  Tianjin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin People's Republic of China"},{"name":"Tianjin International Joint Academy of Biomedicine  Tianjin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Li","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin People's Republic of China"},{"name":"Tianjin International Joint Academy of Biomedicine  Tianjin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihang","family":"Niu","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man","family":"Yuan","sequence":"additional","affiliation":[{"name":"Hebei Edible Bird's Nest Fresh Stew Technology Innovation Center  Langfang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hebei Edible Bird's Nest Fresh Stew Technology Innovation Center  Langfang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongliang","family":"Wang","sequence":"additional","affiliation":[{"name":"Hebei Edible Bird's Nest Fresh Stew Technology Innovation Center  Langfang People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5149-0351","authenticated-orcid":false,"given":"Chunfeng","family":"Xie","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research Nankai University  Tianjin People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"459","article-title":"Review: Known, Emerging, and Remerging Pharyngitis Pathogens","volume":"230","author":"Caldwell J. 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