{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:07:34Z","timestamp":1785366454503,"version":"3.55.0"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Eranthemum pulchellum<\/jats:italic>\n                    Andrews, commonly known as blue sage or blue eranthemum, is used traditionally for treating blisters, skin cracks, and as an antiseptic. Therefore, this study aimed to evaluate the phytochemical profiling and pharmacological properties of the methanolic leaf extract of\n                    <jats:italic>E. pulchellum<\/jats:italic>\n                    (MLEP). MLEP inhibited 1,1\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) and \u03b1\u2010amylase in a dose\u2010dependent manner, with IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 22.32\u00a0\u00b1\u00a01.03 and 34.25\u00a0\u00b1\u00a02.67\u00a0\u00b5g\/mL, respectively, demonstrating its in vitro antioxidant and antidiabetic activity. In vivo, MLEP significantly reduced acetic acid\u2010induced writhing and formalin\u2010induced paw licking in Swiss albino mice, indicating its analgesic properties. Its anxiolytic effects were shown by a notable elevation in time spent as well as entries into the open arms in the elevated plus\u2010maze (EPM), along with increased head dipping in the hole\u2010board test. In the oral glucose tolerance test, MLEP significantly lowered blood glucose levels in mice over 2\u00a0h, highlighting its hypoglycemic effect. A total of eight phytochemicals were identified from MLEP, all of which demonstrated strong binding affinities to key drug target proteins associated with the studied diseases. These findings further validate the results obtained from wet lab experiments. However, further research is required to better comprehend its mode of action and safety profile.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501276","type":"journal-article","created":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T16:20:49Z","timestamp":1758298849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploration of In Vitro and In Vivo Pharmacological Activities of the Ethnomedicinal Plant\n                    <i>Eranthemum pulchellum<\/i>\n                    Andrews, Supported by In Silico Investigation"],"prefix":"10.1002","volume":"22","author":[{"given":"Ayesha","family":"Begum","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nusrat","family":"Afrin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1945-6598","authenticated-orcid":false,"given":"Md. Liakot","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Habibur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neamul","family":"Hoque","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayrin Sultana","family":"Tripty","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mominul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kutub Uddin","family":"Ahamed","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Division BCSIR Dhaka Laboratories Bangladesh Council of Scientific and Industrial Research (BCSIR)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakul","family":"Akter","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"},{"name":"Pharmaceutical Sciences Research Division BCSIR Dhaka Laboratories Bangladesh Council of Scientific and Industrial Research (BCSIR)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8195-7378","authenticated-orcid":false,"given":"Bibi Humayra","family":"Khanam","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109119"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24030605"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr11051384"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27030950"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/729393"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2006.00825.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/life12111692"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60132"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-016-3481-8"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.03.018"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S361194"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4314\/ajtcam.v10i6.32"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.11.035"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2003.tb01345.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2024.105804"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep44083"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2023.100504"},{"key":"e_1_2_11_19_1","first-page":"279","article-title":"Antioxidant and Anxiolytic Activities of Crataegus nigra Wald. et Kit. 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