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Kausel (jabuticaba) is traditionally used by Brazilian indigenous communities for therapeutic purposes, including the treatment of wounds and inflammation. This study investigated the phytochemical composition and biological activities of an ethanolic extract derived from\n                    <jats:italic>P. cauliflora<\/jats:italic>\n                    leaves (ethanolic extract from\n                    <jats:italic>P. cauliflora<\/jats:italic>\n                    leaves [EEPC]). UHPLC\u2010MS phytochemical analysis revealed 13 active phenolic compounds, with gallic acid being the most prevalent at 319.5\u00a0\u00b5g\/mg extract. EEPC demonstrated significant antioxidant activity (IC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a04.42\u00a0\u00b1\u00a00.91\u00a0\u00b5g\/mL, 2,2\u2010diphenyl\u20101\u2010picrylhydrazyl (DPPH) assay), reducing reactive oxygen species (ROS) generation by 63% and inhibiting lipid peroxidation by 63.69%. Furthermore, it exhibited anti\u2010inflammatory effects by decreasing IL\u20101\u03b2 and TNF\u2010\u03b1 levels by 40% and 74%, respectively. Antimicrobial activity was observed against\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    with a minimum inhibitory concentration (MIC) of 250\u00a0\u00b5g\/mL. EEPC also reduced\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    biofilm adhesion by 95.40%. Notably, EEPC enhanced fibroblast migration by 95.40%, suggesting its potential for wound healing. These results highlight the therapeutic potential of EEPC and the value of Brazilian biodiversity for biomedical applications.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501294","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T18:23:30Z","timestamp":1756578210000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Plinia cauliflora<\/i>\n                    Leaf Extract Promotes Wound Healing Through Anti\u2010Inflammatory, Antioxidant, and Antibacterial Actions"],"prefix":"10.1002","volume":"22","author":[{"given":"Priscila de Lima","family":"Paula","sequence":"first","affiliation":[{"name":"Laboratory of Bioactive Natural Products Department of Biochemistry Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana 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Melo","family":"Campos","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products Department of Biochemistry Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thayn\u00e1 Gomes","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products Department of Biochemistry Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ari S\u00e9rgio de Oliveira","family":"Lemos","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products Department of Biochemistry Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalita de Freitas","family":"Souza","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products Department of Biochemistry Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia Rodrigues","family":"Gamarano","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products Department of Biochemistry Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Clara Machado Resende","family":"Guedes","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Microbiology, and Immunology Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira Aparecida Coelho","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Botany Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayrton Senna","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control of Medicines Department of Pharmacy Federal University of Rio Grande Do Norte  Natal Rio Grande do Norte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leandro De Santis","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laboratory of Quality Control of Medicines Department of Pharmacy Federal University of Rio Grande Do Norte  Natal Rio Grande do Norte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Maria","family":"Barbosa\u2010Filho","sequence":"additional","affiliation":[{"name":"Research Institute for Drugs and Medicines Federal University 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-2277","authenticated-orcid":false,"given":"Rodrigo Luiz","family":"Fabri","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Natural Products Department of Biochemistry Institute of Biological Sciences Federal University of Juiz de Fora  Juiz de Fora Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-78310-9_2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.06.019"},{"key":"e_1_2_9_4_1","unstructured":"\u201cWound Care Market Size Share & Trends Analysis by Product (Advanced Traditional) by Application (Chronic Wounds) by End\u2010Use (Hospitals Nursing Homes) by Mode of Purchase by Distribution Channel by Region and Segment Forecasts 2024\u20132030 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