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At the O to W1 ratio of 8.29, the W2 to primary emulsion ratio of 7.62, and the concentration of PLGA was 37.94\u00a0mg\/mL, the entrapment efficiency of sMGP\u2010PLGA was 90.27%. In vitro, at the concentration of 3.125\u201325 \u00b5g\/mL, sMGP\u2010PLGA significantly enhanced the phagocytosis of RAW264.7 macrophages, facilitated the upregulation of surface molecules CD40 and CD86, and increased the secretion of cytokines interferon\u2010gamma (IFN\u2010\u03b3) and interleukin (IL)\u20104, as well as the gene expression levels of toll\u2010like receptor 4 and nuclear factor kappa B. In vivo sMGP\u2010PLGA significantly increased the Newcastle disease antibodies, IFN\u2010\u03b3, and IL\u20106 levels, activated the immune functionality of spleen, thymus, and bursa of Fabricius, and improved the organ index. Meanwhile, sMGP\u2010PLGA promoted the proliferation of T and B lymphocytes. These findings indicate that sMGP\u2010PLGA could enhance the immune activity.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501322","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T17:40:35Z","timestamp":1764092435000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Selenium\n                    <i>Myricaria germanica<\/i>\n                    Polysaccharides\u2010based Nanoparticles to Improve Immune Activity"],"prefix":"10.1002","volume":"23","author":[{"given":"Chunyan","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Traditional Chinese Veterinary Medicine and Animal Health in Fujian Province College of Animal Sciences Fujian Agriculture and Forestry University  Fuzhou P. R. 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