{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:25:27Z","timestamp":1778693127481,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The plant <jats:italic>Zanthoxylum rhetsa<\/jats:italic> has been used for centuries as both food and traditional medicine by the Vietnamese people to treat some diseases. Using various chromatography methods, four earlier unidentified compounds (<jats:bold>1\u20134<\/jats:bold>), along with eight known compounds (<jats:bold>5\u201312<\/jats:bold>), were isolated from the leaves of <jats:italic>Z. rhetsa<\/jats:italic>. The chemical structures of these compounds were elucidated based on the extensive spectroscopic interpretation of HRESIMS, 1D, and 2D NMR spectra. The absolute configurations of compounds <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> were determined by experimental CD spectra. Compounds <jats:bold>3<\/jats:bold> and <jats:bold>7<\/jats:bold> exhibited the most significant inhibition of NO production in LPS\u2010activated RAW264.7 cells, with IC<jats:sub>50<\/jats:sub> values of 45.32 and 67.58\u00a0\u00b5M, respectively, compared to the positive control, dexamethasone, which showed an IC<jats:sub>50<\/jats:sub> value of 13.12\u00a0\u00b5M. The other isolated compounds displayed moderate to low inhibitory effects, with IC<jats:sub>50<\/jats:sub> values ranging from 88.98 to 95.17\u00a0\u00b5M.<\/jats:p>","DOI":"10.1002\/cbdv.202501328","type":"journal-article","created":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T07:19:56Z","timestamp":1749107996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Four Earlier Unidentified Compounds Isolated From <i>Zanthoxylum rhetsa<\/i> and Their NO Inhibitory Activity"],"prefix":"10.1002","author":[{"given":"Bui Thi Mai","family":"Anh","sequence":"first","affiliation":[{"name":"Basic Science Department University of Transport and Communications  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Thi","family":"Mai","sequence":"additional","affiliation":[{"name":"Basic Science Department University of Transport and Communications  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tran Thuy","family":"Nga","sequence":"additional","affiliation":[{"name":"Basic Science Department University of Transport and Communications  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Thi Nha","family":"Trang","sequence":"additional","affiliation":[{"name":"Basic Science Department Hanoi University of Natural Resources and Environment  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan Thi Thuy","family":"Hang","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nguyen Phuong","family":"Thao","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bui Huu","family":"Tai","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0756-6990","authenticated-orcid":false,"given":"Phan","family":"Van Kiem","sequence":"additional","affiliation":[{"name":"Institute of Chemistry, Vietnam Academy of Science and Technology  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"115","article-title":"Traditional Importance, Phytochemicals and Pharmacological Properties of Indian Prickly Ash (Zanthoxylum rhetsa (Roxb.) 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