{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:18:43Z","timestamp":1780597123925,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The study investigates the phytochemical composition and biological activities of essential oil extracted from the rhizomes of Globba racemosa Sm., an underexplored aromatic medicinal herb from the Zingiberaceae family, collected in North Eastern India. Using GC\u2500MS analysis, 42 volatile constituents were identified, representing 91.14% of the total oil, with major compounds including palmitic acid (13.24%), manool (10.4%), \u03b2\u2010caryophyllene (6.61%), sabinene (6.53%), linoleic acid (6.4%), \u03b2\u2010pinene (5.84%) and phytol (4.91%). The essential oil exhibited significant anti\u2010inflammatory effects in LPS\u2010stimulated RAW 264.7 macrophages at 100\u00a0\u00b5g\/mL, remarkably reducing the levels of nitric oxide, prostaglandins and pro\u2010inflammatory mediators (TNF\u2010\u03b1, IL\u20106 and IL\u20101\u03b2). It also demonstrated potent antiproliferative activity against MCF7 (82.16\u00a0\u00b5g\/mL), PC3 (115.45\u00a0\u00b5g\/mL) and HepG2 (158.25\u00a0\u00b5g\/mL) cancer cell lines. 3T3\u2010L1 non\u2010malignant cells were used to test the non\u2010toxic effectiveness of the essential oil, showing no toxicity, with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 758.42\u00a0\u00b5g\/mL. The essential oil showed moderate anti\u2010tyrosinase activity (189.12\u00a0\u00b5g\/mL) compared to kojic acid (91.14\u00a0\u00b5g\/mL) and substantial antioxidant activity in DPPH (64.97\u00a0\u00b5g\/mL) and ABTS (34.28\u00a0\u00b5g\/mL) assays relative to ascorbic acid and BHT standards. These findings highlight the potential of G. racemosa essential oil as a promising therapeutic agent for inflammatory, proliferative and oxidative stress\u2010related disorders.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501329","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T18:55:10Z","timestamp":1756493710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Exploring the Phytochemical Composition with AntiInflammatory, Antiproliferative, Antityrosinase and\u00a0Antioxidant Activities of\n                    <i>Globba racemosa<\/i>\n                    Sm. Essential Oil: An Underexplored Medicinal Plant"],"prefix":"10.1002","volume":"22","author":[{"given":"Swagat","family":"Mohanty","sequence":"first","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhat Kumar","family":"Das","sequence":"additional","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswabhusan","family":"Dash","sequence":"additional","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sucheesmita","family":"Padhee","sequence":"additional","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayushman","family":"Gadnayak","sequence":"additional","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambika","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asit","family":"Ray","sequence":"additional","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Jena","sequence":"additional","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratap Chandra","family":"Panda","sequence":"additional","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-6851","authenticated-orcid":false,"given":"Sanghamitra","family":"Nayak","sequence":"additional","affiliation":[{"name":"Centre For Biotechnology Siksha O Anusandhan (Deemed to Be University)  Bhubaneswar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3732\/ajb.91.1.100"},{"key":"e_1_2_11_3_1","first-page":"154","article-title":"Zingiberaceae in India: Phytogeography and Endemism","volume":"5","author":"Jain S. 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