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This study aimed to evaluate whether the ethanolic extract from\n                    <jats:italic>L. camara<\/jats:italic>\n                    leaves (LCE) influences these processes. Phytochemical analysis by an ultra\u2010fast liquid chromatography\u2010quadrupole time of flight mass spectrometry identified flavonoids and iridoid glycosides in the extract. Cytotoxicity assays using BALB\/c mouse peritoneal macrophages and L929 fibroblasts showed no significant effect on cell viability. Anti\u2010inflammatory activity was assessed through nitric oxide (NO), reactive oxygen species (ROS), lipid bodies (LB), and levels of tumor necrosis factor (TNF)\u2010\u03b1, transforming growth factor (TGF)\u2010\u03b2, and PGE2. LCE significantly reduced NO (74.61\u00a0\u00b1\u00a05.08%), ROS (58.38\u00a0\u00b1\u00a01.77%), and LB formation (53.56\u00a0\u00b1\u00a03.33%), as well as TNF\u2010\u03b1 (40.63\u00a0\u00b1\u00a01.33%), TGF\u2010\u03b2 (88.96\u00a0\u00b1\u00a012.87%), and PGE2 (56.88\u00a0\u00b1\u00a027.10%) levels. Wound healing potential was evaluated via scratch assay, with LCE promoting fibroblast migration up to 86.26\u00a0\u00b1\u00a00.81% after 48 h. These findings indicate that LCE modulates macrophage inflammatory responses and promotes tissue repair, supporting its potential as a natural therapeutic agent for managing inflammation, oxidative stress, and wound healing.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501335","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T17:35:23Z","timestamp":1765820123000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Inflammatory and Lipid Metabolism Modulatory Effects of\n                    <i>Lantana camara<\/i>\n                    L. Extract, With Enhanced Fibroblast Migration"],"prefix":"10.1002","volume":"23","author":[{"given":"Ari S. de O.","family":"Lemos","sequence":"first","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry Institute of Biological Sciences, Federal University of Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus T.","family":"Branca","sequence":"additional","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry Institute of Biological Sciences, Federal University of Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara M.","family":"Campos","sequence":"additional","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry Institute of Biological Sciences, Federal University of Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha S.","family":"Mayrink","sequence":"additional","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry Institute of Biological Sciences, Federal University of Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edvia R.","family":"Gamarano","sequence":"additional","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry Institute of Biological Sciences, Federal University of Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Pedro R. C.","family":"Bastos","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Microbiology, and Immunology Institute of Biological Sciences, Federal University of Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Julia","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry Institute of Biological Sciences, Federal University of Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine S.","family":"Coimbra","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Microbiology, and Immunology Institute of Biological Sciences, Federal University of Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-2277","authenticated-orcid":false,"given":"Rodrigo L.","family":"Fabri","sequence":"additional","affiliation":[{"name":"Bioactive Natural Products Laboratory, Department of Biochemistry Institute of Biological Sciences, Federal University of Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973\u20107847.70902"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291\u2010014\u20100446\u20100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e3182439613"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00737"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.00538"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950\u2010023\u201000347\u2010w"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0306"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S167789"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104004"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.52689\/higea.v12i1.261"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022\u20101759(83)90303\u20104"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1345779"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201019137\u20100"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102\u2010695X2012005000058"},{"key":"e_1_2_10_16_1","volume-title":"Biological Evaluation of Medical Devices. 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