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The aim of the study was to examine whether myricetin could alleviate formaldehyde (FA)\u2010exacerbated asthmatic inflammation through chelation of Fe(II). In this study, FA exposure at 2.0\u00a0mg\/m\n                    <jats:sup>3<\/jats:sup>\n                    exacerbated inflammation in lung tissues and induced iron accumulation and pro\u2010inflammatory responses in pulmonary macrophages (PMs) in ovalbumin\u2010induced asthmatic murine models, which was abated by deferoxamine via Fe(II) removal. Myricetin administration at 100\u00a0mg\/kg relieved FA\u2010exacerbated inflammation and alleviated Fe(II) overload in PMs. Myricetin treatment in isolated PMs cultured in vitro at 50\u00a0\u00b5M also attenuated pro\u2010inflammatory responses of PMs through restoration of iron homeostasis. The results in this study not only showed that FA could enhance inflammatory condition in asthma through increased Fe(II) accumulation in PMs but also demonstrated the anti\u2010inflammatory activity of myricetin via Fe(II) chelation in both FA\u2010exacerbated asthmatic mice and in vitro PMs. Therefore, myricetin has the potential to be developed as a therapeutic agent for inflammatory conditions related to FA exposures.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501341","type":"journal-article","created":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T22:29:24Z","timestamp":1754000964000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Myricetin Alleviates Formaldehyde\u2010Exacerbated Inflammation in Asthmatic Mice Through Inhibition of Ferrous Iron Accumulation in Pulmonary Macrophages"],"prefix":"10.1002","volume":"22","author":[{"given":"Huijuan","family":"Ma","sequence":"first","affiliation":[{"name":"School of Pharmacy East China University of Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyao","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmacy East China University of Science and Technology  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health Anhui University of Science and Technology  Hefei China"},{"name":"Joint Research Center For Occupational Medicine and Health of IHM Anhui University of Science and Technology  Huainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9009-3786","authenticated-orcid":false,"given":"Huan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy East China University of Science and Technology  Shanghai China"},{"name":"School of Public Health Anhui University of Science and Technology  Hefei China"},{"name":"Joint Research Center For Occupational Medicine and Health of IHM Anhui University of Science and Technology  Huainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02479-5"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020342"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11758"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aaf8823"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp-24-193"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156044"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000211Y.0000000015"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.06.045"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(99)00010-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2015.10.015"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.300461"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2025002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg4205"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2011.02.003"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-043021-032816"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm202"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16602"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101512"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-015-9309-6"},{"issue":"1","key":"e_1_2_11_21_1","first-page":"341","article-title":"Formaldehyde Induces the Apoptosis of BMCs of BALB\/c Mice via the PTEN\/PI3K\/Akt Signal Transduction Pathway","volume":"20","author":"Yu G.","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ina.13141"},{"issue":"4","key":"e_1_2_11_23_1","first-page":"277","article-title":"Exposure to Formaldehyde and Its Potential Human Health Hazards","volume":"29","author":"Kim K. 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