{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:04:48Z","timestamp":1773493488929,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.32472590"],"award-info":[{"award-number":["No.32472590"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of cyclic sulfonamides were synthesized through sulfur(VI) fluoride exchange (SuFEx) reactions as potential pesticide candidates. Among the 30 synthesized derivatives, bioassay screening revealed pronounced insecticidal activity against\n                    <jats:italic>Plutella xylostella<\/jats:italic>\n                    , with compound\n                    <jats:bold>G30<\/jats:bold>\n                    demonstrating optimal efficacy (LC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a039.86\u00a0mg\/L). Furthermore, antifungal evaluation against six plant pathogenic fungi via the mycelial growth rate method identified six compounds (\n                    <jats:bold>G11<\/jats:bold>\n                    ,\n                    <jats:bold>G16<\/jats:bold>\n                    ,\n                    <jats:bold>G17<\/jats:bold>\n                    ,\n                    <jats:bold>G19<\/jats:bold>\n                    ,\n                    <jats:bold>G23<\/jats:bold>\n                    , and\n                    <jats:bold>G25<\/jats:bold>\n                    ) with exceptional activity against\n                    <jats:italic>Rhizoctonia solani<\/jats:italic>\n                    , exhibiting EC\n                    <jats:sub>50<\/jats:sub>\n                    values ranging from 5.99 to 17.54\u00a0mg\/L. Notably, compound\n                    <jats:bold>G11<\/jats:bold>\n                    (EC\n                    <jats:sub>50<\/jats:sub>\n                    \u00a0=\u00a05.99\u00a0mg\/L) displayed remarkable preventive (79.20%) and curative (90.73%) efficacy against\n                    <jats:italic>R. solani<\/jats:italic>\n                    on rice plants at 400\u00a0mg\/L. Although these values were marginally lower than those of the commercial fungicide thiabendazole, the results highlight the therapeutic potential of this compound. This study provides new perspectives for developing cyclic sulfonamides as innovative lead structures in agrochemical discovery, demonstrating dual pesticidal and antifungal functionalities worthy of further optimization.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501378","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T18:34:46Z","timestamp":1753554886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["SuFEx Reaction\u2010Driven Synthesis of New Cyclic Sulfonamide Derivatives With Insecticidal and Fungicidal Bioactivities"],"prefix":"10.1002","volume":"22","author":[{"given":"Junjie","family":"Wei","sequence":"first","affiliation":[{"name":"State Key Laboratory of Green Pesticide and Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education South China Agricultural University  Guangzhou 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