{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:14:31Z","timestamp":1773947671390,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In 2024, vector\u2010borne diseases and fungal infections caused millions of deaths worldwide, despite the availability of existing treatments (World Health Organization). These alarming statistics highlight the need for new bioactive compounds with strong microbial activity. In this context, we designed a novel series of chromeno[2,3\u2010\n                    <jats:italic>c<\/jats:italic>\n                    ]pyrazol\u2010(2\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010one derivatives, incorporating the coumarin scaffold, known for its broad biological activities, and the pyrazole moiety, recognized for its pharmacological potential. The synthesis followed a three\u2010step protocol, yielding 14 new analogs with good yields (56%\u201394%). Structural characterization was performed through extensive nuclear magnetic resonance spectroscopy, including one\u2010dimensional (\n                    <jats:sup>1<\/jats:sup>\n                    H and\u00a0\n                    <jats:sup>13<\/jats:sup>\n                    C) and two\u2010dimensional (heteronuclear single\u2010quantum correlation, heteronuclear multiple bond correlation, and correlated spectroscopy) techniques. Antimicrobial evaluations revealed that several derivatives against both drug\u2010susceptible and resistant strains of\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ATCC 25922,\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    ATCC 29213, and\n                    <jats:italic>Bacillus cereus<\/jats:italic>\n                    ATCC 10876, and a clinical isolate of\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    . Notably, compound\n                    <jats:bold>3j<\/jats:bold>\n                    demonstrated potent broad\u2010spectrum activity, with bactericidal and fungicidal properties supported by minimum inhibitory concentration (58\u2013458 \u00b5g\/mL) and minimum bactericidal concentration\/minimum fungicidal concentration (&lt; 4) values. Compound\n                    <jats:bold>1<\/jats:bold>\n                    also showed exceptional fungicidal action, surpassing fluconazole with an activity index near 100%. Structure\u2013activity relationship analysis revealed that electron\u2010withdrawing and hydrophobic substitutions significantly enhanced antimicrobial potency. Overall, these findings highlight chromeno[2,3\u2010c]pyrazol\u2010(2\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010ones emerge as a promising candidate for next\u2010generation anti\u2010infective drug development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501381","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T16:55:17Z","timestamp":1763484917000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synthesis of Chromeno[2,3\u2010c]Pyrazol\u2010(2\n                    <i>H<\/i>\n                    )\u2010one Derivatives: A New Class of Antibacterial and Antifungal Agents"],"prefix":"10.1002","volume":"22","author":[{"given":"Dro","family":"M\u00e9l\u00e8ne","sequence":"first","affiliation":[{"name":"Laboratoire De Constitution et R\u00e9action de La Mati\u00e8re, UFR Sciences des Structures de La Mati\u00e8re et Technologie Universit\u00e9 F\u00e9lix Houphou\u00ebt\u2010Boigny  Abidjan C\u00f4te d'Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouassi","family":"All\u00e9gra","sequence":"additional","affiliation":[{"name":"Laboratoire De Constitution et R\u00e9action de La Mati\u00e8re, UFR Sciences des Structures de La Mati\u00e8re et Technologie Universit\u00e9 F\u00e9lix Houphou\u00ebt\u2010Boigny  Abidjan C\u00f4te d'Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gaslonde","sequence":"additional","affiliation":[{"name":"Laboratoire De Pharmacognosie, Chimie des Substances naturelles Et \u00c9lectrochimie, CNRS, CiTCom Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4573-5978","authenticated-orcid":false,"given":"Souleymane","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Laboratoire De Constitution et R\u00e9action de La Mati\u00e8re, UFR Sciences des Structures de La Mati\u00e8re et Technologie Universit\u00e9 F\u00e9lix Houphou\u00ebt\u2010Boigny  Abidjan C\u00f4te d'Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ballo","family":"Daouda","sequence":"additional","affiliation":[{"name":"Laboratoire De Constitution et R\u00e9action de La Mati\u00e8re, UFR Sciences des Structures de La Mati\u00e8re et Technologie Universit\u00e9 F\u00e9lix Houphou\u00ebt\u2010Boigny  Abidjan C\u00f4te d'Ivoire"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO.Control Antibiotic Misuse or the Drugs won't Work Warn WHO Experts.2023 https:\/\/www.who.int\/europe\/fr\/news\/item\/23\u201011\u20102023\u2010control\u2010antibiotic\u2010misuse\u2010or\u2010the\u2010drugs\u2010won\u2010t\u2010work\u2013warn\u2010who\u2010experts."},{"key":"e_1_2_9_3_1","unstructured":"WHO.Global Leaders Set First Targets to Control Antimicrobial Resistance Crisis.2024 https:\/\/www.who.int\/europe\/news\/item\/27\u201009\u20102024\u2010global\u2010leaders\u2010set\u2010first\u2010targets\u2010to\u2010control\u2010antimicrobial\u2010resistance\u2010crisis."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808203390806"},{"key":"e_1_2_9_5_1","unstructured":"Centers for Disease Control and Prevention (CDC). 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