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In addition, these synthetic derivatives have been shown to exhibit a wide range of activities, including anti\u2010osteoporotic (\u03b1(v)\u03b2(3) antagonists), antioxidant, epidermal growth factor receptor (EGFR) inhibition, protein kinase inhibition, ionotropic effects, \u03b2\u20103 antagonism, anti\u2010allergic, antimalarial, gastric anti\u2010secretory, bronchodilator, anticonvulsant, anti\u2010hypertensive, platelet aggregation inhibition, MDR modulation, adenosine receptor agonist, adrenoceptor antagonist, and pesticide activities. In this review, we attempt to compile and discuss various approaches (Vilsmeier\u2013Haack reaction, Conrad\u2013Limpach reaction, double hetero\u2010annulation process of Michael abducts, the Friedlander synthetic approach) for the synthesis of NPs and the anticancer effect of these derivatives on different targets, including receptor tyrosine kinases (such as EGFR, fibroblast growth factor receptors), casein kinase 2, c\u2010Met kinase, DNA topoisomerase, cannabinoid, and phosphoinositide\u2010dependent kinase 1 (PDK1) receptors with their associated signaling pathways, mechanisms of action, and the structure\u2013activity relationship (SAR). This review offers an in\u2010depth medicinal and pharmacological profile of NPs as anticancer agents, intending to guide researchers in developing novel, selective, effective, and safe anticancer agents.<\/jats:p>","DOI":"10.1002\/cbdv.202501396","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T14:57:12Z","timestamp":1756133832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Medicinal Chemistry Perspective of 1,8\u2010Naphthyridines as Anticancer Agents"],"prefix":"10.1002","volume":"22","author":[{"given":"Anshul","family":"Trivedi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products Central University of Punjab  Bathinda India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adarsh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences and Natural Products 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