{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:40:00Z","timestamp":1773013200046,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Three unprecedented cycloartane triterpenoids (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    ) together with five known congeners (\n                    <jats:bold>4<\/jats:bold>\n                    \u2013\n                    <jats:bold>8<\/jats:bold>\n                    ) were isolated for the first time from the medicinal plant\n                    <jats:italic>Kadsura longipedunculata<\/jats:italic>\n                    . Their structural diversity was characterized by distinct skeletal modifications: compound\n                    <jats:bold>1<\/jats:bold>\n                    represents a rare 3,4\u2010seco\u2010cycloartane derivative featuring a 7\u2010membered ester A\u2010ring formed via Baeyer\u2010Villiger oxidation, compound\n                    <jats:bold>2<\/jats:bold>\n                    is a schisanartane\u2010type nortriterpenoid with unique 3,4:9,10\u2010diseco structural motifs, while compound\n                    <jats:bold>3<\/jats:bold>\n                    exhibits an unprecedented 18,28\u2010demethylated cycloartane skeleton. In addition, five known congeners (\n                    <jats:bold>4<\/jats:bold>\n                    \u2013\n                    <jats:bold>8<\/jats:bold>\n                    ) were cycloartane triterpenoids. Significantly, these structurally modified derivatives represent the first report of such skeletal variations within the\n                    <jats:italic>K. longipedunculata<\/jats:italic>\n                    genus. Structural elucidation and absolute configuration determination were achieved through comprehensive spectroscopic analysis (one\u2010\/two\u2010dimensional nuclear magnetic resonance and high\u2010resolution electrospray ionization\u2010mass spectrometry) complemented by X\u2010ray crystallographic verification and electronic circular dichroism calculation. These compounds were evaluated for their cytotoxicity and anti\u2010inflammatory activity. Compounds\n                    <jats:bold>4<\/jats:bold>\n                    and\n                    <jats:bold>5<\/jats:bold>\n                    could inhibit nitric oxide production with 50% inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) values of 36.45 and 28.38 \u00b5M. Compound\n                    <jats:bold>4<\/jats:bold>\n                    demonstrated concentration\u2010dependent antiproliferative effects against HeLa cervical cancer cells, achieving 68.99% growth inhibition at 40 \u00b5M and an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 21.40 \u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501406","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T19:59:11Z","timestamp":1752609551000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Three New Cycloartane Triterpenoids From the Caulis of\n                    <i>Kadsura longipedunculata<\/i>"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0279-4222","authenticated-orcid":false,"given":"Jianghai","family":"Ye","sequence":"first","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanyan","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenliang","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuling","family":"Luo","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rensong","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang","family":"He","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7524-4489","authenticated-orcid":false,"given":"Juan","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Pharmacy Guizhou University of Traditional Chinese Medicine  Guiyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.04.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200690180"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol902974j"},{"key":"e_1_2_9_5_1","first-page":"1643","article-title":"Research Progress on Nortriterpenoids in Plants of Schisandraceae and Their Pharmacological Activities","volume":"45","author":"Jin Y. P.","year":"2014","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol052161j"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2006.03.108"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/b719905h"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0503303"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/np980291d"},{"key":"e_1_2_9_11_1","first-page":"6073","article-title":"Longipedlactones A\u2013I, Nine Novel Triterpene Dilactones Possessing a Unique Skeleton From Kadsura longipedunculata","volume":"62","author":"Pu J. X.","year":"2006","journal-title":"Cheminform"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200900245"},{"key":"e_1_2_9_13_1","first-page":"249","article-title":"Use of Intensity Quotients and Differences in Absolute Structure Refinement","volume":"69","author":"Simon P.","year":"2013","journal-title":"Acta Crystallographica"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/np900849y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1241018"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(90)80216-4"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ol051155k"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/np030339"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1700247"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070247a"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2008.10.011"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916263"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2010.01119.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2022.105230"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889808042726"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1107\/S2053273314026370"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0108767307043930"},{"key":"e_1_2_9_28_1","volume-title":"Gaussian 09, Revision E.01","author":"Frisch M. J.","year":"2009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physchem-052516-044827"},{"key":"e_1_2_9_30_1","volume-title":"SpecDis, Version 1.64","author":"Bruhn T.","year":"2015"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202501406","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:22:21Z","timestamp":1773008541000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202501406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,15]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/cbdv.202501406"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202501406","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,15]]},"assertion":[{"value":"2025-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01406"}}