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In this work, five novel synthetic compounds were developed and evaluated for their antifungal activity against 24 clinical isolates of\n                    <jats:italic>Trichophyton rubrum<\/jats:italic>\n                    and\n                    <jats:italic>Trichophyton mentagrophytes<\/jats:italic>\n                    . Among them, compound antifungal\n                    <jats:bold>2<\/jats:bold>\n                    demonstrated potent activity at the nanomolar level (ca. 73\u00a0nM), surpassing the efficacy of\n                    <jats:bold>Tb<\/jats:bold>\n                    (ca. 253\u00a0nM), and with less risk of resistance due to its rational molecular design. Molecular docking and molecular dynamics studies, conducted using a model of fungal SQLE (SE), supported the efficacy of compound 2 as a potential antifungal agent and provided reliable structure\u2013activity relationship insights. Our results highlight the potential of combining propiolaldehyde and sulfonamide\u2010based scaffolds to offer a promising foundation for the rational design of next\u2010generation antifungal agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501477","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:17:20Z","timestamp":1770326240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design, Synthesis, Biological Evaluation, and In Silico Analysis of Novel Antifungal Agents Targeting\n                    <i>Trichophyton<\/i>\n                    Species"],"prefix":"10.1002","volume":"23","author":[{"given":"Jorge A.","family":"Cabezas","sequence":"first","affiliation":[{"name":"School of Chemistry University of Costa Rica  San Jos\u00e9 Costa Rica"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda 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