{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:26:53Z","timestamp":1782448013045,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T00:00:00Z","timestamp":1751673600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Two new aromatic milbemycin metabolites with unusual epoxide moiety, milbemycin A\n                    <jats:sub>5<\/jats:sub>\n                    (\n                    <jats:bold>1<\/jats:bold>\n                    ) and 9\u2010O\u2010methylmilbemycin A\n                    <jats:sub>5<\/jats:sub>\n                    (\n                    <jats:bold>2<\/jats:bold>\n                    ), were isolated from the fermentation broth of mutant\n                    <jats:italic>Streptomyces bingchenggensis<\/jats:italic>\n                    HU176. Their structures were established by extensive spectroscopic analysis including 1D and 2D NMR, HRESIMS data, literature data comparison and NMR calculations. Bioassay test showed that these two new milbemycin metabolites exhibited moderate cytotoxic activity against tumor cell lines HepG2 and HCT116.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501487","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T16:38:37Z","timestamp":1751733517000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Two New Aromatic Milbemycin Metabolites With Unusual Epoxide Moiety From Mutant\n                    <i>Streptomyces bingchenggensis<\/i>\n                    HU176"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2504-3472","authenticated-orcid":false,"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Horticultural Biotechnology of Taizhou School of Agriculture and Bioengineering Taizhou Vocational College of Science and Technology  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Jia","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insect College Life Science Huzhou University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohan","family":"Ren","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insect College Life Science Huzhou University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Horticultural Biotechnology of Taizhou School of Agriculture and Bioengineering Taizhou Vocational College of Science and Technology  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiju","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Horticultural Biotechnology of Taizhou School of Agriculture and Bioengineering Taizhou Vocational College of Science and Technology  Taizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoyong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insect College Life Science Huzhou University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Qi","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Biology and Ecological Regulation of Crop Pathogens and Insect College Life Science Huzhou University  Huzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Zhejiang Makohs Biotech Co. 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