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In this way, the dichloromethane phase from leaves of\n                    <jats:italic>Casearia arborea<\/jats:italic>\n                    was phytochemically evaluated in liquid chromatography coupled to high\u2010resolution mass spectrometry, furnishing flavonoid, flavolignan, and phenylpropanoid derivatives, and apocarotenoid terpenoids according to Global Natural Products Social Molecular Networking (GNPS) dereplication. The flavolignans were chemically monitored by liquid chromatography using a UV\u2013Vis detector and purified by a semi\u2010preparative liquid chromatographic system, furnishing tricin, tricin\u20104\u2033\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010(\n                    <jats:italic>threo<\/jats:italic>\n                    \u2010guaiacylglyceryl) ether (salcolin A), and tricin\u20104\u2033\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010(\n                    <jats:italic>erythro<\/jats:italic>\n                    \u2010guaiacylglyceryl) ether (salcolin B). Additionally, it was observed that tricin was able to reduce live cells and increase apoptotic cell lines of papillary thyroid cancer and induced only necrosis in this HTH83 cell line, whereas salcolins A and B induced cell death in anaplastic thyroid cancer, increasing cell necrosis. Still, there is no significant induction of apoptotic cell death or necrosis in papillary thyroid cancer cells.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501489","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T20:50:17Z","timestamp":1757105417000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the Antiproliferative Activity of Flavolignans From the Leaves of\n                    <i>Casearia arborea<\/i>\n                    (Salicaceae)"],"prefix":"10.1002","volume":"22","author":[{"given":"Augusto L.","family":"Santos","sequence":"first","affiliation":[{"name":"Institute of Environmental, Chemical and Pharmaceutical Sciences Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana T.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Biologia Estrutural e Funcional Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Michelli","sequence":"additional","affiliation":[{"name":"Programa De P\u00f3s\u2010Gradua\u00e7\u00e3o em Biologia Estrutural e Funcional Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo E.","family":"Tamura","sequence":"additional","affiliation":[{"name":"Institute of Environmental, Chemical and Pharmaceutical Sciences Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ileana G. S.","family":"de Rubi\u00f3","sequence":"additional","affiliation":[{"name":"Institute of Environmental, Chemical and Pharmaceutical Sciences Federal University of S\u00e3o Paulo S\u00e3o Paulo Brazil"},{"name":"Institute of Environmental, Chemical and Pharmaceutical Sciences Federal University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisi G.","family":"Soares","sequence":"additional","affiliation":[{"name":"Institute of Chemistry Federal University of Alfenas  Alfenas Minas Gerais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo J. 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