{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:50Z","timestamp":1785484910796,"version":"3.56.0"},"reference-count":64,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Goniothalamus simonsii<\/jats:italic>\n                    Hook. f. Thoms., an endangered medicinal plant is endemic to the state of Meghalaya, India. Its wide use in traditional medicine in Meghalaya for treating gastrointestinal complications, throat irritation and typhoid fever, is not matched by scientific reports on its pharmacological attributes. The present investigation evaluated the phytochemical constituents by GC\u2013MS analysis; while bioactivities including antioxidant, antimicrobial and cytotoxicity were assessed by DPPH, agar\u2010well diffusion and MTT methods, respectively. The leaf extract showed elevated content of phenolics (154.76\u00a0\u00b1\u00a07.98\u00a0mg GAE\/g) and flavonoids (55.91\u00a0\u00b1\u00a03.05\u00a0mg QE\/g). GC\u2013MS analysis identified compounds included\n                    <jats:italic>cis<\/jats:italic>\n                    \u2010vaccenic acid, kavain, 3\u2010methoxy\u20102\u2010(quinoxalin\u20106\u2010yliminomethyl), spathulenol, aziridine, stigmasterol,\n                    <jats:italic>n<\/jats:italic>\n                    \u2010hexadecanoic acid, cholest\u20104\u2010en\u20103\u2010one, coniferyl alcohol and so forth. Leaf extract displayed IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 437.38\u00a0\u00b1\u00a013.11\u00a0\u00b5g\/mL in the DPPH assay. The extracts displayed antimicrobial activity (13.21\u201322.63\u00a0mm) against a broad spectrum of bacteria, with minimum inhibitory concentration (MIC) values ranging &gt;\u00a01000\u201358.59\u00a0\u00b5g\/mL. The antiproliferative effect was observed against colon cancer cell line (HT\u201029) with IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 9.8\u00a0\u00b1\u00a07.84\u00a0\u00b5g\/mL. Docking results demonstrated that stigmasterol exhibited the highest binding affinity for target protein CDK2, with docking score of \u22128.9\u00a0kcal\/mol. These findings serve as a catalyst for additional research on\n                    <jats:italic>G. simonsii<\/jats:italic>\n                    as a prospective bioresource for bioactive compounds in future phytotherapeutics.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501513","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T20:25:48Z","timestamp":1761423948000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Phytochemical Profiling, Bioactivity Evaluation and In Silico Insights Onto\n                    <i>Goniothalamus simonsii<\/i>\n                    Hook. f. Thoms.: An Endangered Medicinal Plant"],"prefix":"10.1002","volume":"23","author":[{"given":"Samson Rosly","family":"Sangma","sequence":"first","affiliation":[{"name":"Department of Forestry, School of Sciences Nagaland University  Lumami Nagaland India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9309-7072","authenticated-orcid":false,"given":"Mayur Mausoom","family":"Phukan","sequence":"additional","affiliation":[{"name":"Department of Forestry, School of Sciences Nagaland University  Lumami Nagaland India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhrubajyoti","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Programme of Biotechnology, Faculty of Science Assam Down Town University  Guwahati Assam India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranay Punj","family":"Pankaj","sequence":"additional","affiliation":[{"name":"Department of Zoology, School of Sciences Nagaland University  Lumami Nagaland India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahshi","family":"Chongloi","sequence":"additional","affiliation":[{"name":"Department of Forestry, School of Sciences Nagaland University  Lumami Nagaland India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jksus.2015.02.003"},{"key":"e_1_2_11_3_1","volume-title":"WHO Traditional Medicine Strategy: 2014\u20132023","author":"WHO","year":"2013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13237\u2010022\u201000405\u20103"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180831145800"},{"key":"e_1_2_11_6_1","first-page":"1","article-title":"Phenolic Content and Antioxidant Activities of Goniothalamus umbrosus Extracts","volume":"1","author":"Abdelwahab S. 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