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Identifying host molecular pathways targeted by the virus is essential for drug discovery, whether through repurposing existing drugs or developing new ones. This review examines the molecular mechanisms of SARS\u2010CoV\u20102 infection, including signaling pathways, therapeutic targets, viral entry and replication strategies, and associated clinical features. It also discusses current global infection and mortality trends, clinical management, and prospects for drug development. Data were sourced from major scientific databases. Given the virus's high mutation rate and ongoing impact, multidisciplinary collaboration is needed. Plant\u2010derived compounds and herbal medicines show promise as potential antiviral interventions against coronavirus disease 2019 (COVID\u201019). The information and data on COVID\u201019 were collated from various resources and literature databases such as PubMed, Science Direct, Wiley, Springer, Taylor and Francis, Scopus, Inflibnet, Google, and Google Scholar.<\/jats:p>","DOI":"10.1002\/cbdv.202501534","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:14:56Z","timestamp":1761833696000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Molecular Roadmap of COVID\u201019: From Viral Entry to Therapeutic Targets"],"prefix":"10.1002","volume":"23","author":[{"given":"Afeez Adekunle","family":"Ishola","sequence":"first","affiliation":[{"name":"Developmental Therapeutics Branch (DTB) of the National Cancer Institute (NCI) National Institute of Health (NIH)  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2215-3900","authenticated-orcid":false,"given":"Idris Adewale","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Applied Science Lincoln University College  Petaling Jaya Selangor Malaysia"},{"name":"Mimia Skincare Sdn. 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