{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:17:16Z","timestamp":1788524236277,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T00:00:00Z","timestamp":1748563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Three novel flavonoid derivatives, named dalberavonoids A\u2013C (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    ), were isolated from the roots of\n                    <jats:italic>Dalbergia odorifera<\/jats:italic>\n                    T. C. Chen. The structures of these flavonoid derivatives were determined by comprehensive spectroscopic analyses. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    represent rare examples of isopentenyl\u2010substituted flavanes from the genus\n                    <jats:italic>Dalbergia<\/jats:italic>\n                    . Compound\n                    <jats:bold>3<\/jats:bold>\n                    is a rare flavonoid containing 16 carbon atoms on the carbon skeleton. The inhibitory activities of dalberavonoids A\u2013C against the nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells in vitro were evaluated. Compounds\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>2<\/jats:bold>\n                    exhibited significant inhibitory activities, possessing the minimum inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) values of 9.13 \u00b1 0.11 and 12.58 \u00b1 0.14 \u00b5M. The positive control, indometacin, displayed an inhibitory activity against NO production with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 23.86 \u00b1 0.08 \u00b5M.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501535","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T14:49:44Z","timestamp":1748616584000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Three Novel Flavonoid Derivatives From the Roots of\n                    <i>Dalbergia odorifera<\/i>"],"prefix":"10.1002","author":[{"given":"Wen\u2010Yi","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Ling","family":"Cheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Tian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u2010Ling","family":"Yi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3098-2757","authenticated-orcid":false,"given":"Xue\u2010Ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University  Haikou China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province College of Chemistry and Chemical Engineering Hainan Normal University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Chinese Pharmacopoeia Committee","year":"2020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1016\/j.bmcl.2013.04.032","article-title":"Inhibitory Constituents of the Heartwood of Dalbergia odorifera on Nitric Oxide Production in RAW 264.7 Macrophages","volume":"23","author":"Lee C.","year":"2013","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.03.026"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/09168451.2014.1003128"},{"key":"e_1_2_7_6_1","first-page":"1","volume":"31","author":"Wariss H. 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