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Despite this, a substantial portion of their biosynthetic potential remains untapped. In this study,\n                    <jats:italic>Myrothecium verrucaria<\/jats:italic>\n                    ACCC 38039 was cultivated on a rice\u2010based medium at 25\u00b0C for 30 days to explore its secondary metabolite profile. Seven compounds were isolated and purified by high\u2010performance liquid chromatography, including three previously undescribed \u03b1\u2010pyrone derivatives (compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>3<\/jats:bold>\n                    ) and four known trichothecenes (compounds\n                    <jats:bold>4<\/jats:bold>\n                    \u2013\n                    <jats:bold>7<\/jats:bold>\n                    ). The structures of these compounds were elucidated through one\u2010 and two\u2010dimensional nuclear magnetic resonance spectroscopy and high\u2010resolution electrospray ionization mass spectrometry. Among these newly identified pyrones, compound\n                    <jats:bold>1<\/jats:bold>\n                    exhibited notable antifungal activity, with a minimum inhibitory concentration of 16\u00a0\u00b5g\/mL against both\n                    <jats:italic>Aspergillus niger<\/jats:italic>\n                    and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , underscoring its potential as a promising lead compound for antifungal drug development.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501554","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T20:04:32Z","timestamp":1756411472000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Three New Pyrones With Antifungal Activity From\n                    <i>Myrothecium verrucaria<\/i>\n                    ACCC 38039"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7051-924X","authenticated-orcid":false,"given":"Wei","family":"Lin","sequence":"first","affiliation":[{"name":"Engineering Research Center of Industrial Microbiology (Ministry of Education) Fujian Normal University  Fuzhou China"},{"name":"College of Life Sciences Fujian Normal University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian\u2010bin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Industrial Microbiology (Ministry of Education) Fujian Normal University  Fuzhou China"},{"name":"College of Life Sciences Fujian Normal University  Fuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin\u2010tong","family":"Chen","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Industrial Microbiology (Ministry of Education) Fujian Normal University  Fuzhou 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