{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:02:52Z","timestamp":1773493372407,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T00:00:00Z","timestamp":1760572800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A series of dehydroabietic acid (DHAA) derivatives containing \u03b1,\u03b2\u2010unsaturated ketone moieties were designed, synthesized and evaluated as anticancer agents. The inhibitory activities of target compounds against SW480, HepG2, MDA\u2010MB\u2010231 human cancer cell lines and one normal hepatocyte cell L02 cells were estimated by methylthiazolyldiphenyl\u2010tetrazolium bromide (MTT) assay in vitro. The results indicated that the most promising compound\n                    <jats:bold>2g<\/jats:bold>\n                    displayed the most significant effect against MDA\u2010MB\u2010231 cells with an IC\n                    <jats:sub>50<\/jats:sub>\n                    value of 8.62\u00a0\u00b5M, roughly 10\u2010fold lower than that of parent compound DHAA and fourfold lower than that of 5\u2010Fu. Mechanistic investigations showed that\n                    <jats:bold>2g<\/jats:bold>\n                    efficiently arrested the cell cycle at the G1 phase and induced apoptosis, accompanied by the generation of intracellular reactive oxygen species (ROS), loss of mitochondrial membrane potential, and inhibition of the NF\u2010\u03baB signaling pathway. These results indicated that compound\n                    <jats:bold>2g<\/jats:bold>\n                    might be a promising lead compound for further investigation.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501583","type":"journal-article","created":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T17:29:42Z","timestamp":1760635782000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Design, Synthesis and Antitumor Evaluation of Novel Dehydroabietic Acid Derivatives Bearing an \u03b1,\u03b2\u2010Unsaturated Ketone Moiety"],"prefix":"10.1002","volume":"22","author":[{"given":"Zihan","family":"Fan","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Drug Discovery and Optimization School of Pharmacy Guilin Medical University  Guilin China"},{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Drug Discovery and Optimization School of Pharmacy Guilin Medical University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meishan","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengshan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6651-5259","authenticated-orcid":false,"given":"Rizhen","family":"Huang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Drug Discovery and Optimization School of Pharmacy Guilin Medical University  Guilin China"},{"name":"Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China) Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources School of Chemistry and Pharmaceutical Sciences Guangxi Normal University  Guilin China"},{"name":"Postdoctoral Workstation Liuzhou LMZ Co. 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