{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T13:19:37Z","timestamp":1773494377792,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T00:00:00Z","timestamp":1757030400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160737"],"award-info":[{"award-number":["82160737"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Plantago asiatica<\/jats:italic>\n                    L. (\n                    <jats:italic>PAL<\/jats:italic>\n                    ) is a prevalent perennial herb utilized for both culinary and medicinal purposes. This article examines the impact of deep eutectic solvent (DES, composed of choline chloride and lactic acid) on the pharmacokinetics of chemical constituents in\n                    <jats:italic>PAL<\/jats:italic>\n                    extract. An ultra\u2010high performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC\u2013MS\/MS) method, characterized by high sensitivity and specificity, was developed and validated for the simultaneous quantification of luteolin, oleanolic acid, ursolic acid, verbascoside, apigenin, aucubin, and plantamajoside in rat plasma following oral administration of\n                    <jats:italic>PAL<\/jats:italic>\n                    extract. The chromatographic separation employed an XBridge BEH C18 column, utilizing a mobile phase system composed of a 0.1% (v\/v) formic acid aqueous solution and methanol with gradient elution. The devised approach was effectively used in the pharmacokinetic investigation of these seven analytes from\n                    <jats:italic>PAL<\/jats:italic>\n                    extract in rats. The pharmacokinetic characteristics, including\n                    <jats:italic>C<\/jats:italic>\n                    <jats:sub>max<\/jats:sub>\n                    , AUC\n                    <jats:sub>(0\u2212<\/jats:sub>\n                    <jats:italic>\n                      <jats:sub>t<\/jats:sub>\n                    <\/jats:italic>\n                    <jats:sub>)<\/jats:sub>\n                    , and AUC\n                    <jats:sub>(0\u2212\u221e)<\/jats:sub>\n                    , of\n                    <jats:italic>PAL<\/jats:italic>\n                    extract dissolved in 15% DES (v\/v) via oral administration were superior to those dissolved in water. The findings indicated that DES may enhance the absorption of constituents in\n                    <jats:italic>PAL<\/jats:italic>\n                    extract, extend the duration and concentration of chemical components in vivo, and possibly improve the therapeutic efficacy.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501611","type":"journal-article","created":{"date-parts":[[2025,9,5]],"date-time":"2025-09-05T20:45:07Z","timestamp":1757105107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Deep Eutectic Solvent: Improve the Constituents in\n                    <i>Plantago asiatica<\/i>\n                    L. (\n                    <i>PAL<\/i>\n                    ) Extract Oral Absorption in Rats"],"prefix":"10.1002","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0052-5168","authenticated-orcid":false,"given":"Chuanhua","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital Jiangxi Medical College Nanchang University  Nanchang Jiangxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Children's Hospital of Jiangxi Province  Nanchang Jiangxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital Jiangxi Medical College Nanchang University  Nanchang Jiangxi P. R. 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