{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T08:01:48Z","timestamp":1785484908692,"version":"3.56.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T00:00:00Z","timestamp":1768694400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Acanthospermum hispidum<\/jats:italic>\n                    (AH) leaves have been widely used in traditional medicine for inflammation. In this study, the anti\u2010inflammatory effect of AH was evaluated, and a possible mechanism was predicted using an in silico model. The in vivo anti\u2010inflammatory activity of the AH extract was carried out using carrageenan, histamine and serotonin\u2010induced rat paw oedema, whereas molecular docking was used against all receptors implicated with inflammation. AH extract showed significant (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01) inhibition at 50, 100, 150 and 200\u00a0mg\/kg with all the models used (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u02c2\u00a00.05 to \u02c20.0001) with a non\u2010significant decrease at T180; there were significances at some dose levels (e.g., 150 and 200\u00a0mg\/kg). The peak percentage inhibition of the extract occurred at a dose of 100\u00a0mg\/kg. A dose\u2010dependent increase in anti\u2010inflammatory activity was noted across the time examined T30\u2014T150 with a non\u2010significant decrease at T180. F1 was found to be the most active fraction. However, stigmasterol showed a potent antagonist influence on COX\u20101, COX\u2010II, CAT and INF\u2010gamma by showing binding affinities of \u22128.9, \u22128.9, \u22128.8 and \u22128.4\u00a0kcal\/mol, respectively. Moreover, alkyl, carbon\u2010hydrogen, conventional hydrogen and van der Waals interactions were noted. Stigmasterol was observed to obey the Lipinski rule of five except MLOGP. These findings justify the ethnomedicinal information of the usage of AH in the management of inflammation and related ailments.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501647","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T08:55:48Z","timestamp":1768726548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>Acanthospermum hispidum<\/i>\n                    and Its Metabolite Stigmasterol Modulates Anti\u2010Inflammatory Antagonism of COX\u20101 and TGF\u2010\u03b2"],"prefix":"10.1002","volume":"23","author":[{"given":"Onome Mary","family":"Adeboye","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy University of Lagos  Lagos Nigeria"},{"name":"Department of Pharmacognosy and Herbal medicine, Faculty of Pharmacy Lagos State University, College of Medicine  Lagos Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abimbola","family":"Sowemimo","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy University of Lagos  Lagos Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muyiwa Samuel","family":"Fageyinbo","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics Faculty of Basic Clinical Sciences University of Medical Sciences  Ondo City Ondo State Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwasegun","family":"Adedokun","sequence":"additional","affiliation":[{"name":"Cancer and Reproductive Research Group, College of Pharmacy Igbinedion University  Nigeria"},{"name":"Phytochemistry Laboratory CBIOS \u2013 Research Centre for Bioscience and Health Technologies  Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Basit","sequence":"additional","affiliation":[{"name":"College of Pharmacy Shenzhen Technology University  Shenzhen Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opeyemi Joshua","family":"Olatunji","sequence":"additional","affiliation":[{"name":"University Mohammed VI Polytechnic  Ben Guerir Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6596-8985","authenticated-orcid":false,"given":"Epole Ngolle","family":"Ntungwe","sequence":"additional","affiliation":[{"name":"Department of Organic and Pharmaceutical Chemistry Institut Qu\u00edmic De Sarria Universitat Ramon Llull  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232314905"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1875041901205010001"},{"key":"e_1_2_10_4_1","volume-title":"inflammation","author":"Britannica Editors","year":"2025"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.18203\/2394\u20106040.ijcmph20184250"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101616468"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25163726"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867327999200917150939"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.31254\/phyto.2022.11311"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.07.027"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.55779\/nsb15111414"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-99988-5.00006-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.22038\/IJBMS.2022.60954.13494"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1288382"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002293"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00324"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010798"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.47223\/irjay.2022.5617"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.47223\/IRJAY.2022.5610"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1028303"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000658"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.02.040"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.13040\/IJPSR.0975-8232.2(9).2259-65"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11101912"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13596\u2010020\u201000502\u20101"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.32859\/era.22.47.1\u201027"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.36348\/merjps.2022.v02i01.002"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S118297"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3126\/ije.v4i2.12620"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2021.1935933"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2953930"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crphar.2021.100038"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.4274\/tjps.galenos.2021.48264"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.18311\/jnr\/2002\/346"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.5897\/jmpr2021.7145"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2013.06.020"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2008000500024"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/2698"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2020.1744568"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.09.040"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202501647","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202501647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T07:56:48Z","timestamp":1785484608000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202501647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/cbdv.202501647"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202501647","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01647"}}