{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:57:28Z","timestamp":1790452648953,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T00:00:00Z","timestamp":1760054400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp;amp; Biodiversity"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Bupleuri Radix (BR), a principal botanical drug in traditional Chinese medicine, is valued for its multifaceted pharmacological activities, including anti\u2010inflammatory, analgesic, and hepatoprotective properties. Nevertheless, critical challenges persist concerning the ambiguous botanical authentication of crude origins and inconsistent quality control in processed BR materials. In this study, high\u2010performance liquid chromatography fingerprints were successfully established, and the similarity was 0.814\u20130.923. Subsequently, through hierarchical cluster analysis and principal component analysis, the samples were initially classified into two origins:\n                    <jats:italic>Bupleurum chinense<\/jats:italic>\n                    DC. and\n                    <jats:italic>Bupleurum scorzonerifolium<\/jats:italic>\n                    Willd. Within each origin group, the specimens were further stratified into two subgroups: crude and vinegar\u2010processed BR. Orthogonal partial least squares\u2010discriminant analysis was applied to confirm classification results and obtain the chemical markers. The content determination results showed that Saikosaponin a (SSa) and Saikosaponin d (SSd) in both origins exhibited notable reductions following the vinegar\u2010processing procedure, while Saikosaponin b\n                    <jats:sub>1<\/jats:sub>\n                    (SSb\n                    <jats:sub>1<\/jats:sub>\n                    ) and Saikosaponin b\n                    <jats:sub>2<\/jats:sub>\n                    (SSb\n                    <jats:sub>2<\/jats:sub>\n                    ) demonstrated marked increases. Network pharmacology and molecular docking techniques demonstrated that active molecules have a higher affinity for ALB and CASP3. The methods and results of this study provide a reliable basis for the identification and rational utilization of BR.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.202501653","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T17:14:20Z","timestamp":1760116460000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quality Assessment of Crude and Vinegar\u2010Processed Bupleuri Radix Using High\u2010Performance Liquid Chromatography Fingerprint and Chemometric Analysis"],"prefix":"10.1002","volume":"22","author":[{"given":"Ruimeng","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zicheng","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin 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